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Literature summary for 2.3.1.122 extracted from

  • Goins, C.M.; Dajnowicz, S.; Smith, M.D.; Parks, J.M.; Ronning, D.R.
    Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis (2018), J. Biol. Chem., 293, 3651-3662 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.122

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of Ag85C covalently modified by esterase inhibitor tetrahydrolipstatin Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
S148A mutant lacks observable transesterase activity but exhibits hydrolase activity at a lower level than that of wild-type Mycobacterium tuberculosis
S148T mutant lacks observable transesterase activity but exhibits hydrolase activity at a lower level than that of wild-type Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
tetrahydrolipstatin covalent inhibition. The enzyme undergoes structural changes upon acylation, and positioning of the peptidyl arm of tetrahydrolipstain limits hydrolysis of the acyl-enzyme adduct Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQN8 cf. EC 2.3.1.20
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Mycobacterium tuberculosis CDC 1551 P9WQN8 cf. EC 2.3.1.20
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the binding of the incoming acceptor molecule drives the protein to form an active conformation, the second half-reaction could therefore proceed through a direct or indirect activation pathway upon acceptor molecule binding. The beta-hydroxy group of mycolic acid plays a direct role in the second half-reaction of Ag85 catalysis Mycobacterium tuberculosis ?
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additional information the binding of the incoming acceptor molecule drives the protein to form an active conformation, the second half-reaction could therefore proceed through a direct or indirect activation pathway upon acceptor molecule binding. The beta-hydroxy group of mycolic acid plays a direct role in the second half-reaction of Ag85 catalysis Mycobacterium tuberculosis CDC 1551 ?
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Synonyms

Synonyms Comment Organism
ag85C cf. EC 2.3.1.20 Mycobacterium tuberculosis
antigen 85C
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 Mycobacterium tuberculosis