Application | Comment | Organism |
---|---|---|
medicine | - |
Escherichia coli |
medicine | - |
Homo sapiens |
medicine | inhibitor 5,10-dideazatetrahydrofolate is antiproliferate and cytotoxic against mammalian tumor cells in culture and have broad spectrum activity against transplantable mouse tumors and human tumor xenografts | Mus musculus |
Cloned (Comment) | Organism |
---|---|
cDNA, recombinant enzyme expressed in insect cells with a recombinant baculovirus | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
- |
Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-formyl-5,8-dideazafolic acid hexaglutamate | - |
Mus musculus | |
2',5'-thiophene dideazatetrahydrofolate | LY309887, diastereomer B | Homo sapiens | |
2',5'-thiophene dideazatetrahydrofolate | LY309887, diastereomer B | Mus musculus | |
2-deaminodideazatetrahydrofolate | - |
Mus musculus | |
5,10-dideazatetrahydrofolate | - |
Escherichia coli | |
5,10-dideazatetrahydrofolate | - |
Homo sapiens | |
5,10-dideazatetrahydrofolate | - |
Mus musculus | |
5,8-Dideazafolate | - |
Escherichia coli | |
5,8-dideazafolate hexaglutamate | - |
Mus musculus | |
5,8-dideazapteroyl hexaglutamate | - |
Mus musculus | |
5-deazatetrahydrofolate | - |
Mus musculus | |
dideazatetrahydrofolate | - |
Mus musculus | |
dideazatetrahydrofolate hexaglutamate | - |
Mus musculus | |
homo-dideazatetrahydrofolate | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000075 | - |
10-formyl-5,8-dideazafolate | recombinant enzyme | Mus musculus | |
0.0013 | - |
10-formyl-5,8-dideazafolate | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Gallus gallus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Escherichia coli | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Homo sapiens | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | Mus musculus | carries out the second, third and fifth sequential reactions of de novo purine synthesis pathway | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Gallus gallus | - |
chicken | - |
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
L-1210 cell | murine leukemia | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
7 | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Mus musculus | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Escherichia coli | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
10-formyl-5,8-dideazafolate + carbocyclic beta-glycinamide ribonucleotide | - |
Homo sapiens | 5,8-dideazafolate + N-formyl carbocyclic beta-glycinamide ribonucleotide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | - |
Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Gallus gallus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Escherichia coli | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | essential enzyme in DNA synthesis, third enzyme in de novo purine biosynthesis pathway | Homo sapiens | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide | carries out the second, third and fifth sequential reactions of de novo purine synthesis pathway | Mus musculus | tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide | - |
? | |
additional information | - |
Escherichia coli | ? | - |
? | |
additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Gallus gallus | ? | - |
? | |
additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Mus musculus | ? | - |
? | |
additional information | trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GARFT | - |
Gallus gallus |
GARFT | - |
Mus musculus |
GARFT | - |
Escherichia coli |
GARFT | - |
Homo sapiens |