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Literature summary for 2.1.1.364 extracted from

  • Mahesh, A.; Khan, M.; Govindaraju, G.; Verma, M.; Awasthi, S.; Chavali, P.; Chavali, S.; Rajavelu, A.; Dhayalan, A.
    SET7/9 interacts and methylates the ribosomal protein, eL42 and regulates protein synthesis (2020), Biochim. Biophys. Acta, 1867, 118611 .
    View publication on PubMed
Search for more literature for 2.1.1.364

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8WTS6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + [ribosomal protein eL42]-L-lysine100
-
 Homo sapiens S-adenosyl-L-homocysteine + [ribosomal protein eL42]-N6-methyl-L-lysine100
-
 ?
S-adenosyl-L-methionine + [ribosomal protein eL42]-L-lysine53
-
 Homo sapiens S-adenosyl-L-homocysteine + [ribosomal protein eL42]-N6-methyl-L-lysine53
-
 ?
S-adenosyl-L-methionine + [ribosomal protein eL42]-L-lysine80
-
 Homo sapiens S-adenosyl-L-homocysteine + [ribosomal protein eL42]-N6-methyl-L-lysine80
-
 ?

General Information

General Information Comment Organism
physiological function SET9 interacts with the large subunit ribosomal protein, eL42. The N-terminal MORN domain of SET9 is essential for its interaction with eL42. SET9 methylates eL42 at Lys53, Lys80 and Lys100. SET9-mediated methylation of eL42 enhances global translation Homo sapiens