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Information on EC 2.1.1.364 - [histone H3]-lysine4 N-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.364 [histone H3]-lysine4 N-methyltransferase
IUBMB Comments
This entry describes enzymes that catalyse a single methylation of the L-lysine4 residue of histone H3 (H3K4), generating a monomethylated form. This modifications influence the binding of chromatin-associated proteins and result in gene activation or suppression. Some enzymes that catalyse this reaction continue to generate a trimethylated form; these enzymes are classified under EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
chromatin histone H3-lysine 4 methyltransferase, H3-K4 HMT, histone lysine methyltransferase, histone lysine methyltransferase SET7/9, HKMT, KIAA1717, KMT7, PKMT, protein lysine methyltransferases, SET-domain protein lysine methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a [histone H3]-L-lysine4 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
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PATHWAY SOURCE
PATHWAYS
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