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Literature summary for 2.1.1.364 extracted from
- Understanding product specificity of protein lysine methyltransferases from QM/MM molecular dynamics and free energy simulations: the effects of mutation on SET7/9 beyond the Tyr/Phe switch (2012), J. Chem. Inf. Model., 52, 449-456.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y245A | the mutant acts as a trimethylase | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q8WTS6 | SET7 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + histone L-lysine | the wild-type SET7/9 is a monomethylase | Homo sapiens | S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine | - |
? |  |
| S-adenosyl-L-methionine + TAF10-K189 peptide | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKMT | - |
Homo sapiens |
| protein lysine methyltransferase | - |
Homo sapiens |
| SET7/9 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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