Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | Homo sapiens | - |
S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NQR1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
papillary thyroid cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a [histone H4]-L-lysine20 | - |
Homo sapiens | S-adenosyl-L-homocysteine + a [histone H4]-N6-methyl-L-lysine20 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KMT5a | - |
Homo sapiens |
PR-Set7/9 | - |
Homo sapiens |
SET8 | - |
Homo sapiens |
SETD8 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme expression is upregulated in papillary thyroid carcinoma tissue | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inhibition attenuates proliferation and induces apoptosis. Cell migration and invasion are suppressed in enzyme-knockdown cells. Enzyme inhibition arrests the cell cycle in the G1/S phase of papillary thyroid cancer cells. Enzyme inhibition suppresses the expression of SREBP1, SCD, FASN and ACC, key molecules involved in lipid metabolism and decreases the level of malondialdehyde in papillary thyroid cancer cells | Homo sapiens |
physiological function | the enzyme is an oncogenic factor, specifically a regulator for lipid metabolism in papillary thyroid carcinoma | Homo sapiens |