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Literature summary for 2.1.1.357 extracted from

  • Miyazaki, H.; Higashimoto, K.; Yada, Y.; Endo, T.A.; Sharif, J.; Komori, T.; Matsuda, M.; Koseki, Y.; Nakayama, M.; Soejima, H.; Handa, H.; Koseki, H.; Hirose, S.; Nishioka, K.
    Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing (2013), PLoS Genet., 9, e1003897 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.357

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Mus musculus overall reaction 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
additional information Mus musculus the enzyme does not methylate free histone octamers or (H3-H4)2 tetramers bound to DNA ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q99MY8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Mus musculus 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
additional information the enzyme does not methylate free histone octamers or (H3-H4)2 tetramers bound to DNA Mus musculus ?
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
Ash1L gene name (absent, small, or homeotic discs 1-like) Mus musculus

General Information

General Information Comment Organism
malfunction the enzyme methylates Lys36 of histone H3 to promote the establishment of Hox gene expression by counteracting polycomb silencing Mus musculus