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Information on EC 2.1.1.357 - [histone H3]-lysine36 N-dimethyltransferase

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IUBMB Comments
This entry describes a group of metazoan enzymes that catalyse two successive methylations of lysine36 of histone H3 (H3K36), forming mono- and dimethylated forms. These modifications influence the binding of chromatin-associated proteins. The product can be further methylated to the trimethyl form by EC 2.1.1.358, [histone H3]-dimethyl-L-lysine36 N-methyltransferase. The yeast SET2 enzyme can catalyse all three methylations (see EC 2.1.1.359, [histone H3]-lysine36 N-trimethyltransferase).
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The expected taxonomic range for this enzyme is: Homo sapiens
Reaction Schemes
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2
+
a [histone H3]-L-lysine36
=
2
+
a [histone H3]-N6,N6-dimethyl-L-lysine36
+
a [histone H3]-N6-methyl-L-lysine36
=
+
a [histone H3]-N6,N6-dimethyl-L-lysine36
Synonyms
Ash1L, KMT3B, KMT3C, NSD2, SETMAR, Whsc1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
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overall reaction
-
-
-
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
show the reaction diagram
(1a)
-
-
-
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
show the reaction diagram
overall reaction
-
-
-
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