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Literature summary for 2.1.1.357 extracted from

  • Zhou, X.; Zhu, R.; Wu, X.; Xu, H.; Li, Y.; Xu, Q.; Liu, S.; Huang, H.; Xu, X.; Wan, L.; Wu, Q.; Liu, J.
    NSD2 promotes ventricular remodelling mediated by the regulation of H3K36me2 (2019), J. Cell. Mol. Med., 23, 568-575 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.357

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Mus musculus overall reaction 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 Mus musculus
-
 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BVE8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myocardium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 overall reaction Mus musculus 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
-
 Mus musculus S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
 ?

Synonyms

Synonyms Comment Organism
NSD2
-
 Mus musculus

General Information

General Information Comment Organism
malfunction specific knockout of cardiac enzyme does not lead to ventricular remodelling Mus musculus
physiological function the enzyme promotes ventricular remodelling mediated by the regulation of demethylation of [histone H3]-L-lysine36 Mus musculus