Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + adenine in U6 snRNA | Homo sapiens | - |
S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86W50 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + adenine in U6 snRNA | - |
Homo sapiens | S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA | - |
? | |
S-adenosyl-L-methionine + adenine in U6 snRNA | generation of a comprehensive atlas of methylome uniquely mediated by methyltransferase. METTL16 indirectly impacts manifold methylation targets beyond its consensus target motif (UACm6AGAGAA) | Homo sapiens | S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
METTL16 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | METTL16 depletion decreases MAT2A expression, resulting in reduced intracellular S-adenosyl-L-methionine, a key substrate required for RNA methylation. Loss of METTL16 can result in a transcriptome-wide loss of m6A methylation beyond sites directly methylated by METTL16 | Homo sapiens |