Information on EC 2.1.1.346 - U6 snRNA m6A methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.346 U6 snRNA m6A methyltransferase
IUBMB Comments
This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions .
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
m6A methyltransferase, m6A RNA methyltransferase, methyltransferase like protein 16, methyltransferase-like protein 16, METTL16, N6-methyladenosine (m6A) methyltransferase, RNA m6A methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
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