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Literature summary for 2.1.1.254 extracted from

  • Paulus, T.J.; Tuan, J.S.; Luebke, V.E.; Maine, G.T.; DeWitt, J.P.; Katz, L.
    Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli (1990), J. Bacteriol., 172, 2541-2546.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + erythromycin C Saccharopolyspora erythraea
-
 S-adenosyl-L-homocysteine + erythromycin A
-
 ?
S-adenosyl-L-methionine + erythromycin D Saccharopolyspora erythraea
-
 S-adenosyl-L-homocysteine + erythromycin B
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea A4F7P5
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A (1) Saccharopolyspora erythraea
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + erythromycin C
-
 Saccharopolyspora erythraea S-adenosyl-L-homocysteine + erythromycin A
-
 ?
S-adenosyl-L-methionine + erythromycin D
-
 Saccharopolyspora erythraea S-adenosyl-L-homocysteine + erythromycin B
-
 ?

Synonyms

Synonyms Comment Organism
EryG
-
 Saccharopolyspora erythraea

General Information

General Information Comment Organism
malfunction eryG mutant strain lacks detectable erythromycin O-methyltransferase activity with erythromycin C, erythromycin D, or the analogs 2-norerythromycin C and 2-norerythromycin D as substrates Saccharopolyspora erythraea
physiological function the enzyme catalyzes all of the 3''-O-methylation reactions of the erythromycin biosynthetic pathway in Saccharopolyspora erythraea Saccharopolyspora erythraea