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Literature summary for 2.1.1.208 extracted from

  • Treede, I.; Jakobsen, L.; Kirpekar, F.; Vester, B.; Weitnauer, G.; Bechthold, A.; Douthwaite, S.
    The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose (2003), Mol. Microbiol., 49, 309-318.
    View publication on PubMed
Search for more literature for 2.1.1.208

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + uridine2479 in 23S rRNA Streptomyces viridochromogenes AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89 S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
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Organism

Organism UniProt Comment Textmining
Streptomyces viridochromogenes Q9F5K6
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + uridine2479 in 23S rRNA AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89 Streptomyces viridochromogenes S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
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S-adenosyl-L-methionine + uridine2479 in 23S rRNA AviRb modifies the 2'-O-ribose position of nucleotide uridine2479 within helix 89. The exact position of the modification is conformed by MALDI mass spectrometry, a single methyl group is added. No methylation activity with 16S rRNA Streptomyces viridochromogenes S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
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Synonyms

Synonyms Comment Organism
AviRb
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 Streptomyces viridochromogenes

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 assay at Streptomyces viridochromogenes

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Streptomyces viridochromogenes