Literature summary for 2.1.1.20 extracted from

Tain, L.S.; Jain, C.; Nespital, T.; Froehlich, J.; Hinze, Y.; Groenke, S.; Partridge, L.
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production (2019), Aging Cell, 19, e13043 .

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Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9VG42	-	-
Mus musculus	Q9QXF8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	in the liver of liver-specific IRS1 KO mice, expression of GNMT is increased	Mus musculus
physiological function	reduced insulin/IGF signaling activity modulates methionine metabolism, through tissue-specific regulation of glycine N-methyltransferase Gnmt. This regulation is required for full insulin/IGF signaling-mediated longevity. Fat body-specific expression of Gnmt is sufficient to extend lifespan. Reducing insulin/IGF signaling activity leads to a Gnmt-dependent increase in spermidine levels. Both spermidine treatment and reduced insulin/IGF signaling activity are sufficient to extend the lifespan of Drosophila, but only in the presence of Gnmt	Drosophila melanogaster

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Release 2023.1 (January 2023)