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BRENDA support

Information on EC 2.1.1.20 - glycine N-methyltransferase

for references in articles please use BRENDA:EC2.1.1.20

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IUBMB Comments

This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate . Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
gnmt, glycine n-methyltransferase, glycine methyltransferase, s-adenosyl-l-methionine:glycine n-methyltransferase, glycine-n methyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
glycine betaine biosynthesis IV (from glycine), glycine betaine biosynthesis V (from glycine)