Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of -/- and +/- knockout mutants, Gnmt -/- mice show hepatomegaly, hypermethioninemia, and significantly higher levels of serum alanine aminotransferase and hepatic S-adenosylmethionine, down regulation of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, abnormally high glycogen accumulation in liver, hypoglycemia, increased serum cholesterol, and significantly lower numbers of white blood cells, neutrophils, and monocytes, some genes of gluconeogenesis enzyme significantly down regulated in Gnmt -/- mice | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | major folate binding protein, involved in the regulation of the expression of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, binds benzo(a)pyrene and prevents DNA-adduct formation | ? | - |
? | |
S-adenosyl-L-methionine + glycine | Mus musculus | key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens | S-adenosyl-L-homocysteine + N-methylglycine | N-methylglycine = sarcosine | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
construction of -/- and +/- knockout mutants | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | higher expression level in female than in male mice | Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
additional information | not detected in brain | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | major folate binding protein, involved in the regulation of the expression of S-adenosylhomocysteine hydrolase and formiminotransferase cyclodeaminase, binds benzo(a)pyrene and prevents DNA-adduct formation | Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + glycine | key enzyme for the regulation of the ratio of S-adenosylmethionine to S-adenosylhomocysteine, affects genetic stability by regulating DNA methylation and interacting with environmental carcinogens | Mus musculus | S-adenosyl-L-homocysteine + N-methylglycine | N-methylglycine = sarcosine | ? |
Synonyms | Comment | Organism |
---|---|---|
4S polycyclic aromatic hydrocarbon binding protein | - |
Mus musculus |
GNMT | - |
Mus musculus |
Gnmt gene product | - |
Mus musculus |