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Literature summary for 2.1.1.14 extracted from
- Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli (2009), J. Bacteriol., 191, 3407-3410.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strain MTD23 | Escherichia coli |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C645A | the mutation confers resistance to diamide when cells are grown in media lacking methionine, but not when cells are grown in the presence of methionine, cysteine 645 serves to modulate the activity of MetE in vivo in response to disulfide stress | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Diamide | - |
Escherichia coli |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-methyltetrahydropteroyl-tri-L-glutamate + L-homocysteine | - |
Escherichia coli | tetrahydropteroyl-tri-L-glutamate + L-methionine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cobalamin-independent methionine synthase | - |
Escherichia coli |
| MetE | - |
Escherichia coli |
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