General Stability | Organism |
---|---|
NADPH is not protective against induced inactivation by peroxynitrite | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
peroxynitrite | inactivation of enzyme by formation of nitrotyrosine near the catalytic center, 2.5fold increased Km-value and 1.7fold decreased Vmax, molecular modeling | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
NADPH | - |
Bos taurus | |
0.04 | - |
GSSG | - |
Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | molecular modeling of enzyme inactivation by peroxynitrite, structure analysis | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | mucosa | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSSG + NADPH | - |
Bos taurus | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GR | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Bos taurus |