Application | Comment | Organism |
---|---|---|
medicine | QAO does not possess a protective role in menadione-induced free radical production and DNA damage in human cancer cells. Under aerobic conditions, menadiol produced by QAR is readily oxidized to menadione by two 1-electron steps producing the semiquinone and the parent quinone with concomitant production of superoxide anion, which leads to generation of hydroxyl radicals | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dicoumarol | presence of dicoumarol decreases the production of hydroxyl radical and attenuates DNA strand-breaks in MCF-7 cells treated with menadione | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
menadione + NADPH + H+ | - |
Homo sapiens | menadiol + NADP+ | under aerobic conditions, menadiol is readily oxidized to menadione by two 1-electron steps producing the semiquinone and the parent quinone with concomitant production of superoxide anion, which leads to generation of hydroxyl radicals | ? |
Synonyms | Comment | Organism |
---|---|---|
NADPH quinone acceptor oxidoreductase | - |
Homo sapiens |
QAO | - |
Homo sapiens |