Information on EC - NADPH:quinone reductase

for references in articles please use BRENDA:EC1.6.5.5
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IUBMB Comments
A zinc enzyme, specific for NADPH. Catalyses the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates . Dicoumarol [cf. EC NAD(P)H dehydrogenase (quinone)] and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O2 . In some mammals, the enzyme is abundant in the lens of the eye, where it is identified with the protein zeta-crystallin.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
ArsH, Dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate) (quinone), DT-diaphorase, EC, Flavoprotein NAD(P)H:quinone reductase, Menadione oxidoreductase, Menadione reductase, NAD(P)H dehydrogenase, NAD(P)H dehydrogenase (quinone), NAD(P)H menadione reductase, more
NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone
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