Literature summary for 1.5.3.5 extracted from

Yildiz, I.; Yildiz, B.S.
Mechanistic study of L-6-hydroxynicotine oxidase by DFT and ONIOM methods (2021), J. Mol. Model., 27, 53 .

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Organism

Organism	UniProt	Comment	Textmining
Paenarthrobacter nicotinovorans	Q93NH4	-	-

Synonyms

Synonyms	Comment	Organism
6-HLNO	-	Paenarthrobacter nicotinovorans

General Information

General Information	Comment	Organism
metabolism	resiudes Asn166, Tyr311, and Lys287 as well as an active site water molecule have roles in the catalysis of the enzyme. A hydride transfer mechanism is the only viable mechanism for catalysis. During the hydride transfer process an active site water molecule bridges FAD and Lys287 through H-bonding interaction. A series of H-bonding interactions coupled with van der Waals interactions keep FAD and substrate S-6-hydroxynicotine closer. FAD achieves a bent conformation	Paenarthrobacter nicotinovorans

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Release 2023.1 (January 2023)