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Literature summary for 1.5.1.9 extracted from

  • Battur, B.; Boldbaatar, D.; Umemiya-Shirafuji, R.; Liao, M.; Battsetseg, B.; Taylor, D.; Baymbaa, B.; Fujisaki, K.
    LKR/SDH plays important roles throughout the tick life cycle including a long starvation period (2009), PLoS ONE, 4, e7136.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli and Sf9 insect cells Haemaphysalis longicornis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
 calculated from amino acid sequence Haemaphysalis longicornis

Organism

Organism UniProt Comment Textmining
Haemaphysalis longicornis
-
-
-
Haemaphysalis longicornis
-
 bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase, EC 1.5.8 and EC 1.5.9
-

Source Tissue

Source Tissue Comment Organism Textmining
animal the SDH mRNA transcripts are more abundant in unfed and starved ticks than in fed and engorged ticks Haemaphysalis longicornis
-
midgut
-
 Haemaphysalis longicornis
-
additional information expression in all developmental stages, including a long period of starvation after detachment from the host. The mRNA transcripts are more abundant in unfed and starved ticks than in fed and engorged ticks Haemaphysalis longicornis
-
ovary
-
 Haemaphysalis longicornis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O
-
 Haemaphysalis longicornis L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
lysine-ketoglutarate reductase/saccharopine dehydrogenase
-
 Haemaphysalis longicornis
saccharopine dehydrogenase
-
 Haemaphysalis longicornis
SDH
-
 Haemaphysalis longicornis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Haemaphysalis longicornis

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 10 inactive under acidic (pH 5) or alkaline (pH 10) conditions Haemaphysalis longicornis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Haemaphysalis longicornis

General Information

General Information Comment Organism
physiological function gene silencing by RNAi indicates that the tick LKR/SDH plays an integral role in the osmotic regulation of water balance and development of eggs in ovary of engorged females Haemaphysalis longicornis