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Literature summary for 1.5.1.33 extracted from

  • Kaur, J.; Singh, B.K.; Tripathi, R.P.; Singh, P.; Singh, N.
    Leishmania donovani: a glycosyl dihydropyridine analogue induces apoptosis like cell death via targeting pteridine reductase 1 in promastigotes (2009), Exp. Parasitol., 123, 258-264.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,6-dimethyl-4-(3-O-benzyl-1,2-ortho-isopropylidene-beta-L-threopentofuranos-4-yl)-1-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester treatment with 90 microM GDA resulted in reduction of viable cells from 94.2% (control) to 77.1%, 76.8%, 74.9%, 35.3% and 24.9% at 18, 24, 48, 72 and 96 h, respectively Leishmania donovani

Organism

Organism UniProt Comment Textmining
Leishmania donovani Q6QDB5
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
pteridine reductase 1
-
Leishmania donovani
PTR1
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Leishmania donovani