Literature summary for 1.5.1.20 extracted from

Reljic, A.; Simundic, A.M.; Topic, E.; Nikolac, N.; Justinic, D.; Stefanovic, M.
The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and cancer risk: the Croatian case-control study (2007), Clin. Biochem., 40, 981-985.

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Protein Variants

Protein Variants	Comment	Organism
additional information	the C677T gene polymorphism decreases enzyme activity and does not significantly contribute to the inherited genetic susceptibility to breast and prostate cancer, while there is some evidence for possible genetic contribution of this polymorphism to the development of head and neck carcinoma	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + reduced acceptor	-	Homo sapiens	5-methyltetrahydrofolate + oxidized acceptor	-	?

Synonyms

Synonyms	Comment	Organism
methylenetetrahydrofolate reductase	-	Homo sapiens
MTHFR	-	Homo sapiens

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Release 2023.1 (January 2023)