Literature summary for 1.5.1.2 extracted from

Ding, J.; Kuo, M.L.; Su, L.; Xue, L.; Luh, F.; Zhang, H.; Wang, J.; Lin, T.G.; Zhang, K.; Chu, P.; Zheng, S.; Liu, X.; Yen, Y.
Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers (2017), Carcinogenesis, 38, 519-531 .

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Application

Application	Comment	Organism
medicine	both PYCR1 mRNA and protein expression are significantly associated with tumor size, grade and invasive molecular subtypes of breast cancers. Higher PYCR1 mRNA levels are significantly associated with poor survival of breast cancer patients, regardless of estrogen receptor status. Inhibition of PYCR1 by small-hairpin RNA significantly reduces the growth and invasion capabilities of the cells, while enhancing the cytotoxicity of doxorubicin in breast cancer cell lines MCF-7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor negative). Chemotherapy significantly improves survival in early-stage breast cancer patients with low PYCR1 expression levels	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P32322	isoform PYCR1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Pycr1	-	Homo sapiens

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Release 2023.1 (January 2023)