Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,3aR,5aS,7S,9aS,9bR,11aR)-9a,11a-dimethyl-1-[(2R,3E)-4-phenylbut-3-en-2-yl]-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol | - |
Homo sapiens | |
(1R,3aR,5aS,7S,9aS,9bR,11aR)-9a,11a-dimethyl-1-[(2S)-1-oxopropan-2-yl]-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl acetate | - |
Homo sapiens | |
(20S)-pregn-5-ene-3,20-diol | - |
Homo sapiens | |
(2S)-2-[(1R,3aR,5aS,7S,9aS,9bR,11aR)-7-(acetyloxy)-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]propanoic acid | - |
Homo sapiens | |
(2S)-2-[(1R,3aR,5aS,7S,9aS,9bR,11aR)-7-hydroxy-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-N-methylpropanamide | - |
Homo sapiens | |
(3S,20S)-20-(aminomethyl)-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-(ethoxyaminocarbonyl)-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-(hydroxycarbamoyl)-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-(hydroxymethyl)-pregn-7-en-3-ol | - |
Homo sapiens | |
(3S,20S)-20-(methoxyaminocarbonyl)-pregn-7-en-3-ylacetate | - |
Homo sapiens | |
(3S,20S)-20-(methyl-carbamoyl)-pregn-7-en-3beta-ol | i.e. MGI-21 | Homo sapiens | |
(3S,20S)-20-(N,N-dimethylaminocarbonyl)-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[((E)-2-methylbut-2-enoyloxy)methyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[((E)-but-2-enoyloxy)methyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[(butanoylamino)methyl]-pregn-7-en-3-ylacetate | - |
Homo sapiens | |
(3S,20S)-20-[(dimethylamino)acetoxymethyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[(formyloxy)methyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[(N-methyl-N-butanoylamino)methyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[(N-methyl-N-propanoylamino)methyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[(propanylamino)methyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(3S,20S)-20-[N-methyl-N-(2-methylpropyl)-aminocarbonyl]-pregn-7-en-3-yl acetate | - |
Homo sapiens | |
(7S,9aR,11aS)-1-[(2S)-1-hydroxypropan-2-yl]-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol | - |
Homo sapiens | |
(7S,9aS,11aR)-1-[(2S)-1-hydroxypropan-2-yl]-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl acetate | - |
Homo sapiens | |
3beta-[2-(diethylamino)ethoxy]androst-5-en-17-one | i.e. U18666A | Homo sapiens | |
4-[(E)-2-((3S,20R)-3-hydroxypregn-7-en-20-yl)-ethenyl]-1-methylpyridinium iodide | i.e. DR 258 | Homo sapiens | |
6-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide | i.e. W-7 | Homo sapiens | |
N,N-dimethyl-3beta-hydroxy-cholenamide | - |
Homo sapiens | |
trifluoroperazine | - |
Homo sapiens | |
Triparanol | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7,24-trien-3beta-ol + NADPH + H+ | Homo sapiens | - |
7-dehydrocholesterol + NADP+ | - |
? | |
cholesta-7,24-dien-3beta-ol + NADPH + H+ | Homo sapiens | - |
lathosterol + NADP+ | - |
? | |
desmosterol + NADPH + H+ | Homo sapiens | - |
cholesterol + NADP+ | - |
? | |
lanosterol + NADPH + H+ | Homo sapiens | - |
4,4,14alpha-trimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? | |
zymosterol + NADPH + H+ | Homo sapiens | - |
zymostenol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7,24-trien-3beta-ol + NADPH + H+ | - |
Homo sapiens | 7-dehydrocholesterol + NADP+ | - |
? | |
cholesta-7,24-dien-3beta-ol + NADPH + H+ | - |
Homo sapiens | lathosterol + NADP+ | - |
? | |
desmosterol + NADPH + H+ | - |
Homo sapiens | cholesterol + NADP+ | - |
? | |
lanosterol + NADPH + H+ | - |
Homo sapiens | 4,4,14alpha-trimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? | |
zymosterol + NADPH + H+ | - |
Homo sapiens | zymostenol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DELTA24-dehydrocholesterol reductase | - |
Homo sapiens |
DHCR24 | - |
Homo sapiens |
seladin-1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000001 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-(hydroxymethyl)-pregn-7-en-3-ol | |
0.0000025 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (7S,9aR,11aS)-1-[(2S)-1-hydroxypropan-2-yl]-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol | |
0.0000029 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (1R,3aR,5aS,7S,9aS,9bR,11aR)-9a,11a-dimethyl-1-[(2R,3E)-4-phenylbut-3-en-2-yl]-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-ol | |
0.0000033 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (7S,9aS,11aR)-1-[(2S)-1-hydroxypropan-2-yl]-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl acetate | |
0.0000042 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-[(formyloxy)methyl]-pregn-7-en-3-yl acetate | |
0.0000055 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-[(dimethylamino)acetoxymethyl]-pregn-7-en-3-yl acetate | |
0.0000063 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-[((E)-but-2-enoyloxy)methyl]-pregn-7-en-3-yl acetate | |
0.000198 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-(aminomethyl)-pregn-7-en-3-yl acetate | |
0.000203 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-[((E)-2-methylbut-2-enoyloxy)methyl]-pregn-7-en-3-yl acetate | |
0.000805 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-(methoxyaminocarbonyl)-pregn-7-en-3-ylacetate | |
0.000823 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (2S)-2-[(1R,3aR,5aS,7S,9aS,9bR,11aR)-7-hydroxy-9a,11a-dimethyl-2,3,3a,5,5a,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-N-methylpropanamide | |
0.0169 | - |
at 37°C, pH not specified in the publication | Homo sapiens | (3S,20S)-20-[(butanoylamino)methyl]-pregn-7-en-3-ylacetate |