Cloned (Comment) | Organism |
---|---|
quantitative real-time PCR DHCR24 expression analysis | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-cholest-7-en-3beta-ol + NADP+ | Mus musculus | - |
5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | no activity in J774 cells, that lack a full-length transcript for DHCR24. J774 cells are able to grow indefinitely after the virtually total replacement of cholesterol by desmosterol, i.e. J774-D cells | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-cholest-7-en-3beta-ol + NADP+ | - |
Mus musculus | 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
3beta -hydroxysterol DELTA24-reductase | - |
Mus musculus |
DHCR24 | - |
Mus musculus |
sterol-DELTA24-reductase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | desmosterol suffice as a cholesterol replacement. Although a wide range of sterols and cholesterol analogues such as beta-sitosterol, ergosterol and 5beta-cholestan-3beta-ol are unable to support cell proliferation, while 5alpha-cholestan-3beta-ol, i.e. dihydrocholesterol, can do so, pathway regulation, detailed overview | Mus musculus |
additional information | J774 cells, that lack a full-length transcript for DHCR24, consequently accumulate desmosterol | Mus musculus |
additional information | while cholesterol itself may not be unique in its ability to sustain mammalian life, sterols very much like cholesterol, such as desmosterol, appear to be absolutely required | Mus musculus |