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Literature summary for 1.21.1.1 extracted from

  • Gnidehou, S.; Caillou, B.; Talbot, M.; Ohayon, R.; Kaniewski, J.; Noel-Hudson, M.S.; Morand, S.; Agnangji, D.; Sezan, A.; Courtin, F.; Virion, A.; Dupuy, C.
    Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site (2004), FASEB J., 18, 1574-1576.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transfection of HEK-293 cells results in active protein, but not of CHO cells Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane protein, partly exposed to cell surface, protein accumulates at the apical pole of thyrocytes Sus scrofa 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
x * 33000, SDS-PAGE and calculated Sus scrofa
33000
-
x * 33000, SDS-PAGE and calculated Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6PHW0
-
-
Sus scrofa Q6TA49
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification putative signal peptide with a possible cleavage site between Ala23 and Asp24 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
thyroid
-
Sus scrofa
-
thyroid
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5-diiodo-L-tyrosine + NADPH + H+ substrate 3-iodo-L-tyrosine is preferred over 3,5-diiodotyrosine Sus scrofa 3-iodo-L-tyrosine + NADP+ + I-
-
?
3-iodo-L-tyrosine + NADPH + H+
-
Sus scrofa L-tyrosine + NADP+ + I-
-
?

Subunits

Subunits Comment Organism
? x * 33000, SDS-PAGE and calculated Sus scrofa
? x * 33000, SDS-PAGE and calculated Homo sapiens

Expression

Organism Comment Expression
Sus scrofa DEHAL12 is upregulated by cAMP up