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Information on EC 1.21.1.1 - iodotyrosine deiodinase

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EC Tree
     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
            
                1.21.1.1 iodotyrosine deiodinase
IUBMB Comments
The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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Synonyms
sup-18, dehal1b, dehal1 protein, iodotyrosine dehalogenase 1, nadh oxidase/flavin reductase, sup-18 iyd, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-iodo-L-tyrosine + NADP+ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H+
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(1b)
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L-tyrosine + 2 NADP+ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
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overall reaction
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L-tyrosine + NADP+ + iodide = 3-iodo-L-tyrosine + NADPH + H+
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(1a)
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