Literature summary for 1.21.1.1 extracted from

Gaupale, T.; Mathi, A.; Ravikumar, A.; Bhargava, S.
Localization and enzyme activity of iodotyrosine dehalogenase 1 during metamorphosis of frog Microhyla ornata (2009), Ann. N. Y. Acad. Sci., 1163, 402-406.

Search for more literature for 1.21.1.1

Organism

Organism	UniProt	Comment	Textmining
Microhyla ornata	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	during metamorphosis, DEHAL1 enzyme activity is higher on diiodotyrosine as compared to monoiodotyrosine. Using diiodotyrosine as a substrate, maximal activity is detected at stage 44 in the brain, while it is higher at stage 42 in the tail. With monoiodotyrosine as a substrate, highest activity is detected in the brain at stage 42	Microhyla ornata	-
cerebellum	-	Microhyla ornata	-
infundibular nucleus	ventral part	Microhyla ornata	-
jaw	-	Microhyla ornata	-
mucous gland	-	Microhyla ornata	-
olfactory epithelium	-	Microhyla ornata	-
pituitary gland	-	Microhyla ornata	-
tadpole	tadpole tail fin. During metamorphosis, DEHAL1 enzyme activity is higher on diiodotyrosine as compared to monoiodotyrosine. Using diiodotyrosine as a substrate, maximal activity is detected at stage 44 in the brain, while it is higher at stage 42 in the tail (138.5 U/mg protein). With monoiodotyrosine as a substrate, highest activity is detected in the brain at stage 42	Microhyla ornata	-
ventricular zone	ventricular lining of the fourth ventricle	Microhyla ornata	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
4	-	stage 42, tail	Microhyla ornata
6.1	-	stage 44, lower jaw	Microhyla ornata
6.6	-	stage 46, lower jaw	Microhyla ornata
9.2	-	stage 44, brain	Microhyla ornata
17.9	-	stage 42, lower jaw	Microhyla ornata
24.01	-	stage 44, lower jaw	Microhyla ornata
28.4	-	stage 46, lower jaw	Microhyla ornata
65.8	-	stage 42, brain	Microhyla ornata
109	-	stage 42, brain	Microhyla ornata
118.6	-	stage 44, tail	Microhyla ornata
125	-	stage 46, brain	Microhyla ornata
138.5	-	stage 42, tail	Microhyla ornata
157.7	-	stage 44, brain	Microhyla ornata

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3,5-diiodo-L-tyrosine + NADPH + H+	-	Microhyla ornata	3-iodo-L-tyrosine + NADP+ + I-	-	?
3-iodo-L-tyrosine + NADPH + H+	-	Microhyla ornata	L-tyrosine + NADP+ + I-	-	?

Synonyms

Synonyms	Comment	Organism
DEHAL1	-	Microhyla ornata

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Release 2023.1 (January 2023)