Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0035 | - |
succinate semialdehyde | recombinant enzyme | Rattus norvegicus | |
0.0503 | - |
4-hydroxy-trans-2-nonenal | recombinant enzyme | Rattus norvegicus | |
0.0589 | - |
trans-2-hexenal | recombinant enzyme | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, SDS-PAGE | Rattus norvegicus |
54430 | - |
x * 54430, MALDI-MS | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-trans-2-nonenal + NAD+ | Rattus norvegicus | elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxy-trans-2-nonenal + NAD+ | elevated levels of 4-hydroxy-trans-2-nonenal are implicated in the pathogenesis of numerous neurodegenerative disorders. Succinate-semialdehyde dehydrogenase is the predominant oxidizing enzyme for 4-hydroxy-trans-2-nonenal but only contributes a portion of the total oxidizing activity in liver mitochondria | Rattus norvegicus | ? | - |
? | |
4-hydroxy-trans-2-nonenal + NAD+ + H2O | - |
Rattus norvegicus | 4-hydroxy-trans-2-nonenoate + NADH + H+ | - |
? | |
succinate semialdehyde + NAD+ + H2O | - |
Rattus norvegicus | succinate + NADH + H+ | - |
? | |
trans-2-hexenal + NAD+ + H2O | - |
Rattus norvegicus | trans-2-hexenoate + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, SDS-PAGE | Rattus norvegicus |
? | x * 54430, MALDI-MS | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
SSADH | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus |