Literature summary for 1.2.1.16 extracted from

Walsh, J.M.; Clark, J.B.
Studies on the control of 4-aminobutyrate metabolism in synaptosomal and free rat brain mitochondria (1976), Biochem. J., 160, 147-157.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.4	-	succinate semialdehyde	synaptosomes	Rattus norvegicus
1.5	-	succinate semialdehyde	mitochondria of non-synaptic origin	Rattus norvegicus
9.4	-	NAD+	mitochondria of non-synaptic origin	Rattus norvegicus
17	-	NAD+	synaptosomes	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	of non-synaptic origin	Rattus norvegicus	5739	-
synaptosome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Wistar strain	-
Rattus norvegicus Wistar	-	Wistar strain	-

Purification (Commentary)

Purification (Comment)	Organism
chromatography on Celite 535	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinate semialdehyde + NAD+ + H2O	-	Rattus norvegicus	succinate + NADH + H+	-	r
succinate semialdehyde + NAD+ + H2O	-	Rattus norvegicus Wistar	succinate + NADH + H+	-	r
succinate semialdehyde + NADP+ + H2O	-	Rattus norvegicus	succinate + NADPH + H+	-	?
succinate semialdehyde + NADP+ + H2O	-	Rattus norvegicus Wistar	succinate + NADPH + H+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Rattus norvegicus

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Release 2023.1 (January 2023)