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Information on EC 1.2.1.16 - succinate-semialdehyde dehydrogenase [NAD(P)+]
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1.2.1.16 succinate-semialdehyde dehydrogenase [NAD(P)+]Specify your search results
Word Map
- 1.2.1.16
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gamma-aminobutyric
- seizure
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neurotransmitter
- transaminase
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gamma-hydroxybutyric
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4-hydroxybutyric
- aldh5a1
- epilepsy
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shunt
- aciduria
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subdural
- hematoma
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gabaergic
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ssadhd
- hypotonia
- gaba-transaminase
- gaba-t
- 4-aminobutyrate
- vigabatrin
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neurometabolic
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globus
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tonic-clonic
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pallidi
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2.6.1.19
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hyperintensities
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evacuation
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
succinic semialdehyde dehydrogenase, ssdh, succinate semialdehyde dehydrogenase, succinate-semialdehyde dehydrogenase, spssadh, gabd1, ssa dehydrogenase, cce4228 protein, cce4228, st0064, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BsSSADH
cce4228
cce4228 protein
dehydrogenase, succinate semialdehyde (nicotinamide adenine dinucleotide (phosphate))
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-
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gabD
GabD dehydrogenase
GabD1
gapN-2
NAD(P)+-dependent succinate semialdehyde dehydrogenase
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NAD(P)+-dependent succinic semialdehyde dehydrogenase
NAD+/NADP+-dependent benzaldehyde dehydrogenase
SSA dehydrogenase
SSADH
SSADH-II
SSADHase
SSDH
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SSO1842
ST0064
succinate semialdehyde dehydrogenase
succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))
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succinate-semialdehyde dehydrogenase (NAD(P))
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succinate-semialdehyde dehydrogenase (NAD(P)+)
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succinic semialdehyde dehydrogenase
YneI
additional information
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+
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succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+
mechanism is sequential, consistent with rapid-equilibrium ordered bi-bi system and a steady-state ordered bi-bi system
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succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+
proposed enzymatic mechanism of cce4228 protein, overview
succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+
proposed enzymatic mechanism of cce4228 protein, overview
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
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reduction
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oxidation
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PATHWAY SOURCE
PATHWAYS
KEGG
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SYSTEMATIC NAME
IUBMB Comments
succinate-semialdehyde:NAD(P)+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY
37250-88-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-naphthaldehyde + NAD+ + H2O
2-naphthoate + NADH + H+
low dehydrogenase activity
-
-
?
2-naphthaldehyde + NADP+ + H2O
2-naphthoate + NADPH + H+
low dehydrogenase activity
-
-
?
3-chlorobenzaldehyde + NAD+ + H2O
3-chlorobenzoate + NADH + 2 H+
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-
-
-
?
3-hydroxy-benzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + H+
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good substrate
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-
?
3-hydroxybenzaldehyde + NAD+ + H2O
3-hydroxybenzoate + NADH + 2 H+
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-
-
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?
3-sulfopropanal + NAD(P)+ + H2O
3-sulfopropanoate + NAD(P)H + 2 H+
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-
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?
4-chloro-benzaldehyde + NAD+ + H2O
4-chlorobenzoate + NADH + H+
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good substrate
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?
4-chlorobenzaldehyde + NAD+ + H2O
4-chlorobenzoate + NADH + 2 H+
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?
benzaldehyde + NADP+ + H2O
benzoate + NADPH + 2 H+
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mandelate pathway
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ir
beta-hydroxysuccinic semialdehyde + NADP+ + H2O
beta-hydroxysuccinate + NADPH + H+
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-
-
?
cyclohexanal + NAD+ + H2O
cyclohexanecarboxylic acid + NADH + H+
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good substrate
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?
decanal + NAD+ + H2O
decanoate + NADH + H+
low dehydrogenase activity
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-
?
decanal + NADP+ + H2O
decanoate + NADPH + H+
low dehydrogenase activity
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?
malonic semialdehyde + NADP+ + H2O
malonate + NADPH + H+
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hydrolyzed at 8.7% the rate of succinate semialdehyde
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?
succinate semialdehyde + NAD(P)+ + H2O
succinate + NAD(P)H + 2 H+
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-
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?
succinic semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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-
-
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?
2-oxoglutarate semialdehyde + NAD+ + H2O
2-oxoglutarate + NADH + H+
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-
-
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?
2-oxoglutarate semialdehyde + NAD+ + H2O
2-oxoglutarate + NADH + H+
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-
-
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?
2-oxoglutarate semialdehyde + NADP+ + H2O
2-oxoglutarate + NADPH + H+
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-
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?
2-oxoglutarate semialdehyde + NADP+ + H2O
2-oxoglutarate + NADPH + H+
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?
benzaldehyde + NADP+ + H2O
benzoate + NADPH + H+
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weaker reaction compared to NAD+
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?
benzaldehyde + NADP+ + H2O
benzoate + NADPH + H+
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weaker reaction compared to NAD+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
-
-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
-
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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r
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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r
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + 2 H+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
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?
succinate semialdehyde + NAD+ + H2O
succinate + NADH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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-
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
NADP+ is the preferred cofactor
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
NADP+ is the preferred cofactor
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
NADP+ is the preferred cofactor
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
NADP+ is the preferred cofactor
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
NADP+ is the preferred cofactor
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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r
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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r
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + 2 H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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degradation of 3,4-dihydroxyphenylacetate in Arthrobacter sp.
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
involved in the degradation of gamma-aminobutyrate
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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involved in the degradation of gamma-aminobutyrate
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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involved in the degradation of gamma-aminobutyrate
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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implicated in 4-hydroxyphenylacetic acid and gamma-aminobutyric acid catabolism
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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implicated in 4-hydroxyphenylacetic acid and gamma-aminobutyric acid catabolism
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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implicated in 4-hydroxyphenylacetic acid and gamma-aminobutyric acid catabolism
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
-
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ir
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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at 9% of the rate with NAD+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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involved in the degradation of gamma-aminobutyrate
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
-
involved in the degradation of gamma-aminobutyrate
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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-
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
-
-
-
?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
-
-
-
?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
-
-
-
?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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-
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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pathway for utilization of 4-aminobutyric acid as nitrogen source for Saccharomyces cerevisiae
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?
succinate semialdehyde + NADP+ + H2O
succinate + NADPH + H+
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?
succinic semialdehyde + NAD+ + H2O
succinate + NADH + H+
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?
additional information
?
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protein cce4228 shows similar catalytic efficiency towards succinate semialdehyde (SSA) at saturated concentration of NAD+ or NADP+
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additional information
?
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protein cce4228 shows similar catalytic efficiency towards succinate semialdehyde (SSA) at saturated concentration of NAD+ or NADP+
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additional information
?
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only the aldehyde forms and not the gem-diol forms of the specific substrate succinic semialdehyde , of selected aldehyde substrates, and of the inhibitor 3-tolualdehyde bind to the enzyme. Residue cysteine311 is crucial for their discrimination
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?
additional information
?
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almost no activity with DL-glyceraldehyde, DL-glyceraldehyde 3-phosphate, and glycoaldehyde
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?
additional information
?
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other aldehydes, such as formaldehyde, acetaldehyde and glutaraldehyde, are very poor substrates
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?
additional information
?
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the enzyme is also active with D-glyceraldehyde 3-phosphate (Ga3P), cf. EC 1.2.1.90. Values obtained reflect a 3500 and 87fold higher catalytic efficiency when SSA/NADP+ or SSA/NAD+ pairs, respectively, are used instead of Ga3P/NADP+ or Ga3P/NAD+. Preference for NADP+ when SSA is the substrate
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additional information
?
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the enzyme is also active with D-glyceraldehyde 3-phosphate (Ga3P), cf. EC 1.2.1.90. Values obtained reflect a 3500 and 87fold higher catalytic efficiency when SSA/NADP+ or SSA/NAD+ pairs, respectively, are used instead of Ga3P/NADP+ or Ga3P/NAD+. Preference for NADP+ when SSA is the substrate
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additional information
?
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the enzyme is also active with D-glyceraldehyde 3-phosphate (Ga3P), cf. EC 1.2.1.90. Values obtained reflect a 3500 and 87fold higher catalytic efficiency when SSA/NADP+ or SSA/NAD+ pairs, respectively, are used instead of Ga3P/NADP+ or Ga3P/NAD+. Preference for NADP+ when SSA is the substrate
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additional information
?
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the enzyme is also active with D-glyceraldehyde 3-phosphate (Ga3P), cf. EC 1.2.1.90. Values obtained reflect a 3500 and 87fold higher catalytic efficiency when SSA/NADP+ or SSA/NAD+ pairs, respectively, are used instead of Ga3P/NADP+ or Ga3P/NAD+. Preference for NADP+ when SSA is the substrate
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additional information
?
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the enzyme is also active with D-glyceraldehyde 3-phosphate (Ga3P), cf. EC 1.2.1.90. Values obtained reflect a 3500 and 87fold higher catalytic efficiency when SSA/NADP+ or SSA/NAD+ pairs, respectively, are used instead of Ga3P/NADP+ or Ga3P/NAD+. Preference for NADP+ when SSA is the substrate
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additional information
?
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the enzyme is also active with D-glyceraldehyde 3-phosphate (Ga3P), cf. EC 1.2.1.90. Values obtained reflect a 3500 and 87fold higher catalytic efficiency when SSA/NADP+ or SSA/NAD+ pairs, respectively, are used instead of Ga3P/NADP+ or Ga3P/NAD+. Preference for NADP+ when SSA is the substrate
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additional information
?
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no activity with 2-chlorobenzaldehyde, 3-chlorobenzaldehyde, and acetaldehyde
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?
additional information
?
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no activity is observed with 2-chlorobenzaldehyde
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?
additional information
?
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the 3- and 4-chloro substituents as well as the 3-hydroxy substituent are all electron withdrawing. All these compounds show a reduction in reaction velocity from that of the unsubstituted benzaldehyde
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?
additional information
?
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almost no activity with D,L-glyceraldehyde, D,L-glyceraldehyde-3-phosphate, and D,L-glycolaldehyde
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?
additional information
?
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the enzyme shows no detectable activity with hexanal or benzaldehyde
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?
additional information
?
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the enzyme shows no detectable activity with hexanal or benzaldehyde
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?
additional information
?
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neither propionaldehyde nor phthalaldehyde seves as substrate
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?
additional information
?
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neither propionaldehyde nor phthalaldehyde seves as substrate
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?
additional information
?
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neither propionaldehyde nor phthalaldehyde seves as substrate
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)