Literature summary for 1.2.1.104 extracted from

Pezzato, E.; Battaglia, V.; Brunati, A.; Agostinelli, E.; Toninello, A.
Ca2+-independent effects of spermine on pyruvate dehydrogenase complex activity in energized rat liver mitochondria incubated in the absence of exogenous Ca2+ and Mg2+ (2009), Amino Acids, 36, 449-456.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the E1alpha subunit of PDC regulates the activity of the complex	Rattus norvegicus
spermine	in the absence of exogenous Ca2+ and Mg2+ and in the presence of EGTA, which favours the release of endogenous Ca2+, spermine is able to stimulate the activity of pyruvate dehydrogenase complex (maximum stimulation of about 140% at 0.5 mM after 30 min of incubation, at concentrations higher than 0.5 mM, spermine still stimulates PDC, when compared with the control, but shows a slight dose-dependent decrease). The interaction of spermine with PDC may also involve activation of pyruvate dehydrogenase kinase, resulting in an increase in E1alpha phosphorylation and consequently reduced stimulation of PDC at high polyamine concentrations	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pyruvate + CoA + NAD+	Rattus norvegicus	-	acetyl-CoA + CO2 + NADH	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + CoA + NAD+	-	Rattus norvegicus	acetyl-CoA + CO2 + NADH	-	?

Synonyms

Synonyms	Comment	Organism
PDC	-	Rattus norvegicus
pyruvate dehydrogenase complex	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Rattus norvegicus
thiamine diphosphate	-	Rattus norvegicus

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Release 2023.1 (January 2023)