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Information on EC 1.2.1.104 - pyruvate dehydrogenase system

for references in articles please use BRENDA:EC1.2.1.104

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IUBMB Comments

The pyruvate dehydrogenase system (PDH) is a large enzyme complex that belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.25, branched-chain α-keto acid dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.4.1.27, glycine cleavage system, and EC 2.3.1.190, acetoin dehydrogenase system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and a dihydrolipoamide dehydrogenase (E3). The reaction catalysed by this system is the sum of three activities: EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring) (E1), EC 2.3.1.12, dihydrolipoyllysine-residue acetyltransferase (E2), and EC 1.8.1.4, dihydrolipoyl dehydrogenase (E3). The mammalian system also includes E3 binding protein, which is involved in the interaction between the E2 and E3 subunits.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
pdh complex, pyruvate dehydrogenase system, mrp-3, pdhe1alpha1, pyruvate dehydrogenase alpha subunit, dihydrolipoyllysine-residue acetyltransferase component, plastidial pyruvate dehydrogenase complex, e1 component of pyruvate dehydrogenase complex, pdhalpha, pdh-e1 catalytic subunit, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
show the reaction diagram
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pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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