Literature summary for 1.14.19.30 extracted from

Lopez-Vicario, C.; Gonzalez-Periz, A.; Rius, B.; Moran-Salvador, E.; Garcia-Alonso, V.; Lozano, J.; Bataller, R.; Cofan, M.; Kang, J.; Arroyo, V.; Claria, J.; Titos, E.
Molecular interplay between DELTA5/DELTA6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis (2014), Gut, 63, 344-355 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
CP-24879	the combined DELTA5 desaturase/DELTA6 desaturase inhibitor significantly reduces intracellular lipid accumulation and inflammatory injury in hepatocytes	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60427	-	-
Mus musculus	Q920L1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	increased expression of DELTA5 desaturase and DELTA6 desaturase at both mRNA and protein level are confirmed in livers from mice with high-fat diet-induced obesity and non-alcoholic steatohepatitis (NASH)	Mus musculus	-

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Release 2023.1 (January 2023)