Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | an integral membrane metalloenzyme | Methylococcus capsulatus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | an integral membrane metalloenzyme, the enzyme has a dicopper active site, structures of the dicopper site of enzyme pMMO, overview. Possible peroxo state of the dicopper site of pMMO from combined quantum mechanics and molecular mechanics calculations. The pMMO active site is considered to contain two Cu ions with a Cu-Cu distance of about 2.58 A within the pmoB subunit. One copper is coordinated by two histidine imidazoles, and another is chelated by a histidine imidazole and primary amine of an N-terminal histidine. The QM region contains the two Cu ions, His33, His137, His139, Tyr374, and Glu35 for the resting state, and, in addition, two oxygen atoms for the peroxo state | Methylococcus capsulatus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methylococcus capsulatus | G1UBD1 AND Q607G3 | alpha- and beta-subunits | - |
Methylococcus capsulatus Bath | G1UBD1 AND Q607G3 | alpha- and beta-subunits | - |
Subunits | Comment | Organism |
---|---|---|
heterotrimer | the enzyme consists of three subunits, pmoB, pmoA, and pmoC, organized in an alpha3beta3gamma3 trimer | Methylococcus capsulatus |
Synonyms | Comment | Organism |
---|---|---|
particulate methane monooxygenase | - |
Methylococcus capsulatus |
pMMO | - |
Methylococcus capsulatus |
General Information | Comment | Organism |
---|---|---|
additional information | the enzyme has a dicopper active site, analysis of the resting state and a possible peroxo state of the dicopper active site of pMMO by using combined quantum mechanics and molecular mechanics calculations on the basis of reported X-ray crystal structure, PDB ID 1YEW, of the resting state of pMMO. The pMMO active site is considered to contain two Cu ions with a Cu-Cu distance of about 2.58 A within the pmoB subunit. One copper is coordinated by two histidine imidazoles, and another is chelated by a histidine imidazole and primary amine of an N-terminal histidine. Possible Formation of a Peroxo Species in the Dicopper Site of pMMO, overview | Methylococcus capsulatus |