BRENDA - Enzyme Database
show all sequences of 1.14.16.5

Exome sequencing identifies two variants of the alkylglycerol monooxygenase gene as a cause of relapses in visceral leishmaniasis in children, in Sudan

Marquet, S.; Bucheton, B.; Reymond, C.; Argiro, L.; El-Safi, S.H.; Kheir, M.M.; Desvignes, J.P.; Beroud, C.; Mergani, A.; Hammad, A.; Dessein, A.J.; J. Infect. Dis. 216, 22-28 (2017) View publication on PubMed

Data extracted from this reference:

Engineering
Protein Variants
Commentary
Organism
K234R
the mutation is associated with relapses in visceral leishmaniasis
Homo sapiens
R405X
the mutation is associated with relapses in visceral leishmaniasis
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
Homo sapiens
-
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
-
745497
Homo sapiens
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
AGMO
-
Homo sapiens
Engineering (protein specific)
Protein Variants
Commentary
Organism
K234R
the mutation is associated with relapses in visceral leishmaniasis
Homo sapiens
R405X
the mutation is associated with relapses in visceral leishmaniasis
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
Homo sapiens
-
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
-
745497
Homo sapiens
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
?
Other publictions for EC 1.14.16.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745497
Marquet
Exome sequencing identifies t ...
Homo sapiens
J. Infect. Dis.
216
22-28
2017
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2
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1
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6
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2
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1
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1
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1
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745840
de Rond
Oxidative cyclization of prod ...
Pseudoalteromonas rubra
Nat. Chem. Biol.
13
1155-1157
2017
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1
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1
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2
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1
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4
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1
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745589
Alrayes
The alkylglycerol monooxygena ...
Homo sapiens
J. Neurol. Sci.
363
240-244
2016
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1
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1
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1
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5
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1
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746303
Watschinger
Tetrahydrobiopterin and alkyl ...
Mus musculus
Proc. Natl. Acad. Sci. USA
112
2431-2436
2015
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-
-
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1
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6
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5
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1
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1
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1
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5
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1
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-
-
726881
Tokuoka
Alkylglycerol monooxygenase as ...
Mus musculus
Biochem. Biophys. Res. Commun.
436
306-312
2013
-
-
1
-
2
-
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-
1
-
1
2
-
3
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2
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2
1
2
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1
1
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2
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1
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1
2
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2
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2
1
-
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-
-
1
1
1
1
-
-
727650
Watschinger
Alkylglycerol monooxygenase ...
Danio rerio, Caenorhabditis elegans, no activity in Drosophila melanogaster, Rattus norvegicus
IUBMB Life
65
366-372
2013
-
-
1
-
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1
3
3
6
-
12
-
-
1
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1
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-
13
3
3
-
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3
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1
3
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1
3
3
6
-
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1
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1
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13
3
-
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-
1
1
-
-
-
726903
Watschinger
Catalytic residues and a predi ...
Homo sapiens
Biochem. J.
443
279-286
2012
-
-
1
-
18
-
1
2
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1
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1
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1
1
1
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1
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2
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1
1
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18
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2
1
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2
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1
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1
1
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716754
Watschinger
Identification of the gene enc ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
107
13672-13677
2010
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1
-
1
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1
2
1
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14
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2
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1
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1
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1
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1
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1
1
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2
1
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2
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696542
Watschinger
Glyceryl ether monooxygenase r ...
Rattus norvegicus
Biol. Chem.
390
3-10
2009
-
-
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-
7
-
2
-
-
1
-
1
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-
1
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-
1
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3
-
1
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1
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1
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1
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7
-
-
2
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-
1
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1
-
1
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-
3
-
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-
1
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-
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-
-
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-
688220
Werner
Widespread occurrence of glyce ...
Rattus norvegicus
J. Lipid Res.
48
1422-1427
2007
-
-
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-
-
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-
2
1
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-
1
-
4
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-
1
1
-
16
-
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2
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1
1
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-
1
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7
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7
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2
1
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1
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1
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16
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2
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1
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-
1
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-
-
438648
Taguchi
Glyceryl-ether monooxygenase [ ...
Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Meriones sp., Mesocricetus auratus, Mus musculus, Rattus norvegicus
Med. Res. Rev.
18
43-89
1998
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20
23
1
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10
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1
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7
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1
49
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6
5
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6
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21
5
23
1
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7
-
1
49
-
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438652
Taguchi
-
Glyceryl-ether monooxygenase [ ...
Rattus norvegicus
J. Chem. Soc. Perkin Trans. I
1997
303-307
1997
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1
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1
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1
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1
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2
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-
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-
438645
Armarego
-
Glyceryl-ether monooxygenase [ ...
Rattus norvegicus
Pteridines
7
90
1996
-
-
-
-
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-
1
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1
-
1
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1
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5
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1
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1
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1
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1
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1
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5
-
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438650
Taguchi
-
Glyceryl-ether monooxygenase [ ...
Rattus norvegicus
Pteridines
6
45-57
1995
-
-
-
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-
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-
1
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1
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6
-
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1
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6
-
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-
-
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-
438646
Kosar-Hashemi
-
Glyceryl-ether monooxygenase [ ...
Rattus norvegicus
Pteridines
5
1-7
1994
-
-
-
-
-
-
-
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1
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1
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1
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1
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438647
Kurisu
-
Glyceryl-ether monooxygenase [ ...
Rattus norvegicus
Pteridines
5
95-101
1994
-
-
-
-
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-
4
1
1
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1
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1
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1
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4
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4
4
1
1
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1
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1
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438653
Taguchi
Glyceryl-ether monooxygenase ( ...
Rattus norvegicus
Biol. Chem. Hoppe-Seyler
375
329-334
1994
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-
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-
2
-
1
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1
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1
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1
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1
3
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1
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2
3
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1
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1
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1
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438649
Kosar-Hashemi
Glyceryl ether monooxygenase [ ...
Rattus norvegicus
Adv. Exp. Med. Biol.
338
93-96
1993
-
-
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-
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2
2
-
-
-
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-
1
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1
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2
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2
2
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1
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438651
Kosar-Hashemi
A convenient spectrophotometri ...
Rattus norvegicus
Biol. Chem. Hoppe-Seyler
374
9-25
1993
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-
11
14
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1
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17
-
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1
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3
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3
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13
-
14
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17
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1
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438643
Ishibashi
Affinity purification of alkyl ...
Rattus norvegicus
J. Lipid Res.
26
393-395
1985
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1
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6
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7
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1
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438640
Ishibashi
Solubilization and partial cha ...
Rattus norvegicus
Eur. J. Biochem.
132
23-27
1983
3
-
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3
1
1
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1
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6
-
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1
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3
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2
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1
1
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1
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3
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1
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3
-
1
1
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1
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1
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3
-
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2
-
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-
1
1
-
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-
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438644
Rock
Stimulation of the microsomal ...
Rattus norvegicus
Biochim. Biophys. Acta
450
469-473
1976
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1
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2
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3
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438642
Snyder
Tetrahydropteridine-dependent ...
Rattus norvegicus
Biochim. Biophys. Acta
316
259-265
1973
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1
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1
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438639
Soodsma
Partial characterization of th ...
Rattus norvegicus
J. Biol. Chem.
247
3923-3929
1972
3
-
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-
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-
8
-
1
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1
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1
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1
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1
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1
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3
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2
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438641
Pfleger
The biocleavage of isomeric gl ...
Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Limax maximus, Meriones sp., Mesocricetus auratus, Mus musculus, Rattus norvegicus
Biochim. Biophys. Acta
144
633-648
1967
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