Exome sequencing identifies two variants of the alkylglycerol monooxygenase gene as a cause of relapses in visceral leishmaniasis in children, in Sudan

Marquet, S.; Bucheton, B.; Reymond, C.; Argiro, L.; El-Safi, S.H.; Kheir, M.M.; Desvignes, J.P.; Beroud, C.; Mergani, A.; Hammad, A.; Dessein, A.J.; J. Infect. Dis. 216, 22-28 (2017)

Data extracted from this reference:

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

1-alkyl-sn-glycerol + tetrahydrobiopterin + O2

Homo sapiens

-

1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

1-alkyl-sn-glycerol + tetrahydrobiopterin + O2

-

745497

Homo sapiens

1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O

-

-

-

?

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

1-alkyl-sn-glycerol + tetrahydrobiopterin + O2

Homo sapiens

-

1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O

-

-

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

1-alkyl-sn-glycerol + tetrahydrobiopterin + O2

-

745497

Homo sapiens

1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O

-

-

-

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

745497

Marquet

Exome sequencing identifies t ...

Homo sapiens

J. Infect. Dis.

216

22-28

2017

-

-

-

-

2

-

-

-

-

-

-

1

-

6

-

-

-

-

-

2

-

-

1

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

2

-

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-

-

-

-

-

-

1

-

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-

-

-

2

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

745840

de Rond

Oxidative cyclization of prod ...

Pseudoalteromonas rubra

Nat. Chem. Biol.

13

1155-1157

2017

-

-

1

-

-

-

1

-

-

2

-

1

-

4

-

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-

-

-

-

1

-

1

-

-

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-

-

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-

1

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-

-

1

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2

-

1

-

-

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-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

745589

Alrayes

The alkylglycerol monooxygena ...

Homo sapiens

J. Neurol. Sci.

363

240-244

2016

-

-

-

-

1

-

-

-

1

-

-

1

-

5

-

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-

1

-

1

-

-

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-

1

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1

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-

1

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-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

746303

Watschinger

Tetrahydrobiopterin and alkyl ...

Mus musculus

Proc. Natl. Acad. Sci. USA

112

2431-2436

2015

-

-

-

-

-

-

-

-

-

-

-

1

-

6

-

-

-

-

-

5

-

-

1

-

1

-

-

-

-

-

-

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-

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-

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-

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-

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1

-

-

-

-

-

5

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

726881

Tokuoka

Alkylglycerol monooxygenase as ...

Mus musculus

Biochem. Biophys. Res. Commun.

436

306-312

2013

-

-

1

-

2

-

-

-

1

-

1

2

-

3

-

-

-

-

-

2

-

-

2

1

2

-

-

-

-

-

-

-

1

-

-

-

-

-

1

1

-

2

-

-

-

-

-

1

-

1

2

-

-

-

-

-

2

-

-

2

1

-

-

-

-

-

-

-

-

1

1

1

1

-

-

727650

Watschinger

Alkylglycerol monooxygenase ...

Danio rerio, Caenorhabditis elegans, no activity in Drosophila melanogaster, Rattus norvegicus

IUBMB Life

65

366-372

2013

-

-

1

-

-

-

-

-

1

3

3

6

-

12

-

-

1

-

-

1

-

-

13

3

3

-

-

-

-

-

-

-

3

-

-

-

-

-

1

3

-

-

-

-

-

-

-

1

3

3

6

-

-

-

1

-

1

-

-

13

3

-

-

-

-

-

-

-

-

-

1

1

-

-

-

726903

Watschinger

Catalytic residues and a predi ...

Homo sapiens

Biochem. J.

443

279-286

2012

-

-

1

-

18

-

1

2

-

-

1

-

-

1

-

-

-

-

-

-

-

-

1

1

1

-

-

-

-

-

-

-

1

-

-

2

-

-

1

1

-

18

-

2

1

-

2

-

-

1

-

-

-

-

-

-

-

-

-

1

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

716754

Watschinger

Identification of the gene enc ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

107

13672-13677

2010

-

-

1

-

1

-

1

2

1

-

-

-

-

14

-

-

-

-

-

-

-

-

2

-

1

-

-

-

-

-

-

-

-

-

-

1

-

-

1

-

-

1

-

1

1

-

2

1

-

-

-

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

696542

Watschinger

Glyceryl ether monooxygenase r ...

Rattus norvegicus

Biol. Chem.

390

3-10

2009

-

-

-

-

-

-

7

-

2

-

-

1

-

1

-

-

1

-

-

1

-

-

3

-

1

-

-

-

-

1

-

-

1

-

-

-

-

-

-

1

-

-

-

-

7

-

-

2

-

-

1

-

-

-

1

-

1

-

-

3

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

688220

Werner

Widespread occurrence of glyce ...

Rattus norvegicus

J. Lipid Res.

48

1422-1427

2007

-

-

-

-

-

-

-

2

1

-

-

1

-

4

-

-

1

1

-

16

-

-

2

-

1

1

-

-

-

1

-

-

7

-

-

-

-

-

-

7

-

-

-

-

-

-

2

1

-

-

1

-

-

-

1

-

16

-

-

2

-

1

-

-

-

1

-

-

-

-

-

-

-

-

-

438648

Taguchi

Glyceryl-ether monooxygenase [ ...

Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Meriones sp., Mesocricetus auratus, Mus musculus, Rattus norvegicus

Med. Res. Rev.

18

43-89

1998

-

-

-

-

-

-

20

23

1

-

-

-

-

10

-

-

-

1

-

7

-

1

49

-

-

-

-

-

-

-

-

-

6

5

-

-

-

-

-

6

-

-

-

-

21

5

23

1

-

-

-

-

-

-

-

-

7

-

1

49

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438652

Taguchi

-

Glyceryl-ether monooxygenase [ ...

Rattus norvegicus

J. Chem. Soc. Perkin Trans. I

1997

303-307

1997

-

-

-

-

-

-

-

-

-

-

-

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-

1

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-

-

-

-

1

-

-

2

-

-

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-

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-

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-

-

1

-

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-

-

1

-

-

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-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438645

Armarego

-

Glyceryl-ether monooxygenase [ ...

Rattus norvegicus

Pteridines

7

90

1996

-

-

-

-

-

-

-

-

1

-

-

1

-

1

-

-

-

-

-

1

-

-

5

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

1

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

1

-

-

5

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438650

Taguchi

-

Glyceryl-ether monooxygenase [ ...

Rattus norvegicus

Pteridines

6

45-57

1995

-

-

-

-

-

-

-

1

-

-

-

-

-

1

-

-

-

-

-

-

-

-

6

-

-

-

-

-

-

-

-

-

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-

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-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

6

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438646

Kosar-Hashemi

-

Glyceryl-ether monooxygenase [ ...

Rattus norvegicus

Pteridines

5

1-7

1994

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438647

Kurisu

-

Glyceryl-ether monooxygenase [ ...

Rattus norvegicus

Pteridines

5

95-101

1994

-

-

-

-

-

-

4

1

1

-

-

-

-

1

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

4

-

-

-

-

-

-

-

-

-

-

4

4

1

1

-

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438653

Taguchi

Glyceryl-ether monooxygenase ( ...

Rattus norvegicus

Biol. Chem. Hoppe-Seyler

375

329-334

1994

-

-

-

-

-

-

2

-

1

-

-

-

-

1

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

1

3

-

-

-

-

-

1

-

-

-

-

2

3

-

1

-

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438649

Kosar-Hashemi

Glyceryl ether monooxygenase [ ...

Rattus norvegicus

Adv. Exp. Med. Biol.

338

93-96

1993

-

-

-

-

-

-

2

2

-

-

-

-

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

1

2

-

-

-

-

-

1

-

-

-

-

2

2

2

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438651

Kosar-Hashemi

A convenient spectrophotometri ...

Rattus norvegicus

Biol. Chem. Hoppe-Seyler

374

9-25

1993

-

-

-

-

-

-

11

14

-

-

-

-

-

1

-

-

-

-

-

-

-

-

17

-

-

-

-

-

-

1

-

-

3

-

-

-

-

-

-

3

-

-

-

-

13

-

14

-

-

-

-

-

-

-

-

-

-

-

-

17

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

438643

Ishibashi

Affinity purification of alkyl ...

Rattus norvegicus

J. Lipid Res.

26

393-395

1985

-

-

-

-

-

-

-

-

1

-

2

-

-

6

-

-

1

-

-

7

-

-

1

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

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-

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-

-

1

-

2

-

-

-

-

1

-

7

-

-

1

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438640

Ishibashi

Solubilization and partial cha ...

Rattus norvegicus

Eur. J. Biochem.

132

23-27

1983

3

-

-

-

-

-

3

1

1

-

1

-

-

6

-

-

1

-

-

3

-

-

2

-

-

-

-

-

-

1

1

-

1

-

-

-

3

-

-

1

-

-

-

-

3

-

1

1

-

1

-

-

-

-

1

-

3

-

-

2

-

-

-

-

-

1

1

-

-

-

-

-

-

-

-

438644

Rock

Stimulation of the microsomal ...

Rattus norvegicus

Biochim. Biophys. Acta

450

469-473

1976

-

-

-

-

-

-

1

-

2

-

-

-

-

3

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

2

-

-

-

-

-

-

-

-

2

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438642

Snyder

Tetrahydropteridine-dependent ...

Rattus norvegicus

Biochim. Biophys. Acta

316

259-265

1973

-

-

-

-

-

-

-

-

1

-

-

-

-

1

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

438639

Soodsma

Partial characterization of th ...

Rattus norvegicus

J. Biol. Chem.

247

3923-3929

1972

3

-

-

-

-

-

8

-

1

-

-

-

-

1

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

1

-

-

2

1

-

-

3

-

-

2

-

-

-

-

8

1

-

1

-

-

-

-

-

-

-

-

1

-

-

1

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

438641

Pfleger

The biocleavage of isomeric gl ...

Canis lupus familiaris, Cavia porcellus, Oryctolagus cuniculus, Limax maximus, Meriones sp., Mesocricetus auratus, Mus musculus, Rattus norvegicus

Biochim. Biophys. Acta

144

633-648

1967

-

-

-

-

-

-

-

-

8

-

-

-

-

8

-

-

-

-

-

8

1

-

16

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

8

-

-

-

-

-

-

-

-

8

1

-

16

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-