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Information on EC 1.14.16.5 - alkylglycerol monooxygenase
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1.14.16.5 alkylglycerol monooxygenaseIUBMB Comments
The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron , reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol. The co-product, 4a-hydroxytetrahydropteridine, is rapidly dehydrated to 6,7-dihydropteridine, either spontaneously or by EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase.
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Word Map
- 1.14.16.5
- alkylglycerols
- tetrahydrobiopterin
- hydroxylases
- bh4
-
tetrahydrobiopterin-dependent
- biopterin
- pterins
- tetrahydropterins
- dihydropteridine
-
phenylketonuria
- sepiapterin
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
+
+
=
+
+
+
=
+
a 4a-hydroxy-5,6,7,8-tetrahydropteridine
Synonyms
alkylglycerol monooxygenase, glyceryl ether monooxygenase, glyceryl-ether monooxygenase, alkylglycerol mono-oxygenase, o-alkylglycerol monooxygenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AGMO
alkylglycerol monooxygenase
EC 1.14.99.17
-
-
formerly
-
glyceryl ether hydroxylase
-
-
-
-
glyceryl ether monooxygenase
glyceryl ether oxidase
-
-
-
-
glyceryl ether oxygenase
-
-
-
-
glyceryl ether-cleaving enzyme
-
-
-
-
glyceryl etherase
-
-
-
-
glyceryl-ether cleaving enzyme
-
-
-
-
O-alkylglycerol monooxygenase
-
-
-
-
oxygenase, glyceryl ether mono-
-
-
-
-
alkylglycerol monooxygenase
-
-
-
-
glyceryl ether monooxygenase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
1-O-alkyl-sn-glycerol + a 5,6,7,8-tetrahydropteridine + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
1-O-alkyl-sn-glycerol + a 5,6,7,8-tetrahydropteridine + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
mechanism
-
1-O-alkyl-sn-glycerol + a 5,6,7,8-tetrahydropteridine + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
The glyceryl ether substrate is first hydroxylated in a pteridine-dependent monooxygenase reaction to yield the unstable semiacetal product. The enzyme accepts a range of chain lengths from n = 11 to n = 20. The tetrahydrobiopterin cofactor is first converted to a 4alpha-hydroxy derivative and leaves the reaction after dehydration as 6,7[8H]-dihydrobiopterin, which is recycled to tetrahydrobiopterin by dihydropteridine reductase with NADH or NADPH. The semiacetal rearranges to the corresponding aldehyde and glycerol. In the presence of oxygen, the aldehyde is readily oxidized to the corresponding acid
-
1-O-alkyl-sn-glycerol + a 5,6,7,8-tetrahydropteridine + O2 = 1-O-(1-hydroxyalkyl)-sn-glycerol + a 4a-hydroxy-5,6,7,8-tetrahydropteridine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
1-alkyl-sn-glycerol,tetrahydrobiopteridine:oxygen oxidoreductase
The enzyme cleaves alkylglycerols, but does not cleave alkenylglycerols (plasmalogens). Requires non-heme iron [7], reduced glutathione and phospholipids for full activity. The product spontaneously breaks down to form a fatty aldehyde and glycerol. The co-product, 4a-hydroxytetrahydropteridine, is rapidly dehydrated to 6,7-dihydropteridine, either spontaneously or by EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase.
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CAS REGISTRY NUMBER
COMMENTARY
37256-82-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2R)-3-hexadecyloxypropan-1,2-diol + 2-amino-5,6,7,8-tetrahydropteridin-4-one + O2
?
-
-
-
-
?
(2R)-3-octadecyloxypropan-1,2-diol + 2-amino-5,6,7,8-tetrahydropteridin-4-one + O2
?
-
-
-
-
?
(2RS,1'R)-[1-3H1]-hexadecyloxypropane-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
only 6.5% release of the tritium after 20 min, reaction is stereospecific for the pro-HS hydrogen
-
-
?
(2RS,1'S)-[1-3H1]-hexadecyloxypropane-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
release of 37% of the tritium after 20 min, reaction is stereospecific for the pro-HS hydrogen
-
-
?
(2S)-3-hexadecyloxypropan-1,2-diol + 2-amino-5,6,7,8-tetrahydropteridin-4-one + O2
?
-
the oxygen transfer to 1'C of the aliphatic side-chain is highly stereospecific
-
-
?
(2S)-3-octadecyloxypropan-1,2-diol + 2-amino-5,6,7,8-tetrahydropteridin-4-one + O2
?
-
-
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H2O
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + tetrahydrobiopterin + O2
glycerophosphocholine + alkylaldehyde + dihydrobiopterin + H2O
-
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine is lyso-platelet activating factor
-
-
?
1-O-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
1-O-hexadecyl-sn-glycero-3-phosphocholine + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
1-O-hexadecylglycerol + tetrahydrobiopterin + O2
1-O-(1-hydroxy-hexadecyl)-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
r
1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2
1-hydroxypyrenedecyl-sn-glycerol + dihydrobiopterin + H2O
-
1-O-pyrenedecyl-sn-glycerol and high-performance liquid chromatographic analysis of reaction mixtures with fluorescence detection, overview
further formation of 1-pyrenedecanoic acid
-
?
1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2
?
-
activity assay
-
-
?
1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2
? + dihydrobiopterin + H2O
-
-
-
-
?
1-O-pyrenedecyl-sn-glycerol + tetrahydrobiopterin + O2
glycerol + pyrenedecanal + 6,7[8H]-dihydrobiopterin + H2O
-
-
-
-
?
1-O-pyrenenonyl-sn-glycerol + tetrahydrobiopterin + O2
?
-
activity assay
-
-
?
2-(1-hexadecyloxy)propan-1,3-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-(1-octadecyloxy)ethanol + RS-(cis)-6,7-dimethyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-(1-octadecyloxy)ethanol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-1'-n-hexadecyloxyethanol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-1'-n-octadecyloxyethanol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-hexadecyloxy-ethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-hexadecyloxyethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-hexadecyloxypropane-1,3-diol + 6-methyl-5,6,7,8-tetrahydropterin
?
-
-
-
-
?
2-hexadecylthioethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-octadecyloxyethan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
2-octadecylthioethan-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
3-(1-octadecylthio)propan-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
3-1'-hexadecyloxy-2-methoxy-propan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
3-1'-hexadecyloxy-2-methoxy-propan-2-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
3-1'-n-hexadecylthiopropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
3-1'-n-octadecylthiopropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
3-hexadecyloxy-1-methoxypropan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin
?
-
-
-
-
?
3-hexadecyloxy-2-methoxypropan-1-ol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
3-O-hexadecyl glycerol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
alkylglycerol + tetrahydrobiopterin + O2
glycerol + fatty aldehyde + 6,7[8H]-dihydrobiopterin + H2O
-
-
after rapid decay of the resulting unstable primary product (hemiacetal)
-
?
batyl alcohol + 6R-5,6,7,8-tetrahydrobiopterin + O2
?
-
i.e. RS-3-(1-octadecyloxy)propan-1,2-doiol
-
-
?
batyl alcohol + RS-(cis)-6,7-dimethyl-5,6,7,8-tetrahydropterin + O2
?
-
i.e. RS-3-(1-octadecyloxy)propan-1,2-diol
-
-
?
cis-RS-3-octadec-9'-enyloxypropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
lyso-alkyl-glycerol phospholipid + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol + 6,7-[8]-dihydrobiopterin + H2O
-
-
-
-
?
prodigiosin + tetrahydrobiopterin + O2
cycloprodigiosin + dihydrobiopterin + H2O
-
-
-
-
?
R-3-(1-octadecyloxy)propan-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-dodecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-eicosanyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-heneicosanyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-heptadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-hexadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-nonadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-octadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-pentadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-tridecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
R-3-undecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-(1-heptyloxy)propan-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin
?
-
-
-
-
?
RS-3-(1-hexadecyloxy)-1-methoxypropan-2-ol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-(1-hexadecyloxy)-2-hydroxypropane-1-phosphocholine + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-(1-hexadecyloxy)propan-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-(1-hexadecyloxy)propan-1-ol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-(1-oleyloxy)propan-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-docosanyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-dodecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-heptyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-hexyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-nonyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-octyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-pentyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-propyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-3-tetradecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-cyclohexylmethoxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-hexadecylthiopropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
RS-octadecylthiopropane-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
S-3-(1-hexadecyloxy)-2-hydroxypropane-1-phosphocholine + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
S-3-(1-octadecyloxy)propan-1,2-diol + RS-6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
S-3-octadecyloxypropan-1,2-diol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
(RS)-batyl alcohol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
-
-
-
?
(RS)-batyl alcohol + 6-methyl-5,6,7,8-tetrahydropterin + O2
?
-
i.e. (RS)-3-octadecyloxypropane-1,2-diol, R(+)- and S(-)-6-methyl-5,6,7,8-tetrahydropterin are about equally effective
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H2O
-
enzyme plays an essential role in conjugation with the cleavage enzyme in the regulation of cellular levels of -alkyl moieties in glycerolipids
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
-
-
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
Meriones sp.
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
-
-
-
?
hexadecylglycerol + tetrahydrobiopterin + O2
hexadecanal + glycerol + dihydrobiopterin + H2O
-
1-O-hexadecylglycerol
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2
?
-
good substrate
-
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2
?
-
good substrate
-
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2
?
-
good substrate
-
-
?
additional information
?
-
-
catalyses the cleavage of lipid ethers into glycerol and the corresponding aldehyde
-
-
?
additional information
?
-
-
1-O-alkyl-sn glycerol-3-phosphate is no substrate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H2O
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine + tetrahydrobiopterin + O2
glycerophosphocholine + alkylaldehyde + dihydrobiopterin + H2O
-
1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine is lyso-platelet activating factor
-
-
?
1-O-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
lyso-alkyl-glycerol phospholipid + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol + 6,7-[8]-dihydrobiopterin + H2O
-
-
-
-
?
prodigiosin + tetrahydrobiopterin + O2
cycloprodigiosin + dihydrobiopterin + H2O
-
-
-
-
?
additional information
?
-
-
catalyses the cleavage of lipid ethers into glycerol and the corresponding aldehyde
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-hydroxyalkyl-sn-glycerol + dihydrobiopterin + H2O
-
enzyme plays an essential role in conjugation with the cleavage enzyme in the regulation of cellular levels of -alkyl moieties in glycerolipids
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
?
1-alkyl-sn-glycerol + tetrahydrobiopterin + O2
1-O-alkyl-sn-glycerol + dihydrobiopterin + H2O
-
-
-
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
-
-
-
?
1-O-alkyl-sn-glycerol 3-phosphate + tetrahydrobiopterin + O2
1-O-(1-hydroxyalkyl)-sn-glycerol 3-phosphate + 6,7-[8]-dihydrobiopterin + H2O
-
-
-
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2
?
-
good substrate
-
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2
?
-
good substrate
-
-
?
lyso-platelet activating factor + tetrahydrobiopterin + O2
?
-
good substrate
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(6RS)-6,7-dimethyltetrahydropterin
-
94.2% of the activity with 6R-tetrahydrobiopterin
(6RS)-6-hydroxymethyltetrahydropterin
-
16% of the activity with 6R-tetrahydrobiopterin
(6RS)-6-methyltetrahydropterin
-
60.9% of the activity with 6R-tetrahydrobiopterin
(6RS)-tetrahydrodictyopterin
-
44.7% of the activity with 6R-tetrahydrobiopterin
(6RS)-tetrahydroneopterin
-
124% of the activity with 6R-tetrahydrobiopterin
(6S)-tetrahydrobiopterin
-
3.5% of the activity with 6R-tetrahydrobiopterin
(RS)-6-methyl-5,6,7,8-tetrahydropterin
-
R(+)- and S(-)-6-methyl-5,6,7,8-tetrahydropterin are about equally effective
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Iron
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-(1-octadecylthio)ethanol
-
reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
3-(1-octadecylthio)propan-1,2-diol
-
0.5 mM, 64% inhibition, reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
8-Hydroxyquinoline-5-sulfonic acid
-
1.0 mM, 13% inhibition, reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
hexadecan-1,2-diol
-
reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
Triton X-100
-
6% loss of activity at 0.1% detergent and 59% loss of activity at 0.3% detergent
1,10-phenanthroline
-
1.0 mM, 68% inhibition, reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
8-hydroxyquinoline
-
1.0 mM, 15% inhibition, reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin; reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
EDTA
-
5 mM, 16% inhibition, reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
NEM
-
8.0 mM; 91% inhibition, reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
octadecan-1-ol
-
0.1 mM, 15% inhibition, reaction with RS-batyl alcohol and 6-methyl-5,6,7,8-tetrahydropterin
octadecan-1-ol
-
noncompetitive inhibition of the reaction with RS-3-(1-hexadecyloxy)-2-hydroxypropane-1-phosphocholine and RS-6-methyl-5,6,7,8-tetrahydropterin
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE