Application | Comment | Organism |
---|---|---|
analysis | a Dugesia japonica TPH antibody is a useful marker for serotonergic neurons in planarians | Dugesia japonica |
Cloned (Comment) | Organism |
---|---|
gene TPH, DNA and amino acid sequence determination and analysis | Dugesia japonica |
Protein Variants | Comment | Organism |
---|---|---|
additional information | TPH knockout, by RNAi, animals shows reduced serotonin levels compared to wild-type animals | Dugesia japonica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | Dugesia japonica | the enzyme is required for serotonin, i.e. 5-hydroxytryptamine, biosynthesis | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dugesia japonica | A7VKD9 | a planarian, gene TPH | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | expression pattern of TPH in whole animals, in situ hybridization, overview | Dugesia japonica | - |
nervous system | main expression of gene TPH at commissure axonal connections in the ventral nerve cords | Dugesia japonica | - |
neuron | serotonergic | Dugesia japonica | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + tetrahydrobiopterin + O2 | - |
Dugesia japonica | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? | |
L-tryptophan + tetrahydrobiopterin + O2 | the enzyme is required for serotonin, i.e. 5-hydroxytryptamine, biosynthesis | Dugesia japonica | 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | a conserved leucine zipper in the C-terminal domain is required for the tetramerization of TPH, overview | Dugesia japonica |
Synonyms | Comment | Organism |
---|---|---|
TPH | - |
Dugesia japonica |
tryptophan hydroxylase | - |
Dugesia japonica |