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Literature summary for 1.14.14.94 extracted from

  • Johnson, A.L.; Edson, K.Z.; Totah, R.A.; Rettie, A.E.
    Cytochrome P450 omega-hydroxylases in inflammation and cancer (2015), Adv. Pharmacol., 74, 223-262 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.94

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q08477
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney CYP4F3B Homo sapiens
-
liver CYP4F3B Homo sapiens
-
neutrophil CYP4F3A Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP4 omega-hydroxylase
-
 Homo sapiens
CYP4F3 CYP4F3 undergoes tissue-specific alternative splicing to CYP4F3A and CYP4F3B Homo sapiens

General Information

General Information Comment Organism
physiological function CYP4F3B plays a central role in the inactivation and elimination of leukotrienes from systemic circulation during the resolution of inflammation Homo sapiens