Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Co-protoporphyrin | - |
Bos taurus | |
additional information | HO-1 is induced by epibatidine via neuronal nicotinic acetylcholine receptors and ERK1/2 in the neuroprotective signaling cascade, overview | Bos taurus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | de novo synthesis of the heme proteins on a membrane-coupled template, and screening for heme proteins with heme oxygenase activity, overview | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Sn(IV) protoporphyrin IX dichloride | SnPP | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Bos taurus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Bos taurus | HO-1 is a critical cell defence enzyme against oxidative stress, HO-1 participates in the protective effect afforded by neuronal nicotinic acetylcholine receptors, nAChR, activation, which activates the neuroprotective signaling cascade, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | Q5E9F2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | chromaffin cells | Bos taurus | - |
chromaffin cell | adrenal medulla | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Bos taurus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 is a critical cell defence enzyme against oxidative stress, HO-1 participates in the protective effect afforded by neuronal nicotinic acetylcholine receptors, nAChR, activation, which activates the neuroprotective signaling cascade, overview | Bos taurus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | screening for heme proteins with heme oxygenase activity after de novo synthesis of the heme proteins on a membrane-coupled template, overview | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Bos taurus |
HO-1 | - |
Bos taurus |