Literature summary for 1.14.14.178 extracted from

Asami, T.; Mizutani, M.; Fujioka, S.; Goda, H.; Min, Y.K.; Shimada, Y.; Nakano, T.; Takatsuto, S.; Matsuyama, T.; Nagata, N.; Sakata, K.; Yoshida, S.
Selective interaction of triazole derivatives with DWF4, a cytochrome P450 monooxygenase of the brassinosteroid biosynthetic pathway, correlates with brassinosteroid deficiency in planta (2001), J. Biol. Chem., 276, 25687-25691.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
bitertanol	i.e. 2,3,3-trimethyl-1-biphenyl4-yloxy-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, Kd value is 0.0467 mM	Arabidopsis thaliana
brassinazole	addition of brassinazole to the DWF4 protein induces a type II absorbance shift of the heme Soret band from 416 to 421 nm indicative of direct coordination of the triazole group of the brassinazole to the heme iron of DWF4. Kd value for brassinazole is 0.000001 M	Arabidopsis thaliana
Brz117	i.e. 4-(3-methoxyphenyl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)butan-2-ol, Kd value is 0.0117 mM	Arabidopsis thaliana
difenoconazole	Kd value is 0.0453 mM	Arabidopsis thaliana

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	heme iron	Arabidopsis thaliana

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Synonyms

Synonyms	Comment	Organism
Dwf4	-	Arabidopsis thaliana

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome P450	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)