Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.14.14.178 - steroid 22S-hydroxylase

for references in articles please use BRENDA:EC1.14.14.178
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This plant cytochrome P-450 (heme thiolate) enzyme participates in the biosynthesis of brassinosteroids. While in vivo substrates include C28 steroids such as campestanol, campesterol, and 6-oxocampestanol, the enzyme is able to catalyse the C-22 hydroxylation of a variety of C27, C28 and C29 steroids.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The enzyme appears in viruses and cellular organisms
Reaction Schemes
a C27-steroid
+
+
[reduced NADPHhemoprotein reductase]
=
a (22S)-22-hydroxy-C27-steroid
+
2
+
[oxidized NADPHhemoprotein reductase]
a C28-steroid
+
+
[reduced NADPHhemoprotein reductase]
=
a (22S)-22-hydroxy-C28-steroid
+
2
+
[oxidized NADPHhemoprotein reductase]
a C29-steroid
+
+
[reduced NADPHhemoprotein reductase]
=
a (22S)-22-hydroxy-C29-steroid
+
2
+
[oxidized NADPHhemoprotein reductase]
Synonyms
dwarf4, cyp90b1, c-22 hydroxylase, cyp724b2, cyp724a1, cyp90b3, steroid 22-hydroxylase, br c-22 hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a C27-steroid + O2 + [reduced NADPH—hemoprotein reductase] = a (22S)-22-hydroxy-C27-steroid + 2 H2O + [oxidized NADPH—hemoprotein reductase]
show the reaction diagram
(1)
-
-
-
a C28-steroid + O2 + [reduced NADPH—hemoprotein reductase] = a (22S)-22-hydroxy-C28-steroid + 2 H2O + [oxidized NADPH—hemoprotein reductase]
show the reaction diagram
(2)
-
-
-
a C29-steroid + O2 + [reduced NADPH—hemoprotein reductase] = a (22S)-22-hydroxy-C29-steroid + 2 H2O + [oxidized NADPH—hemoprotein reductase]
show the reaction diagram
(3)
-
-
-
Select items on the left to see more content.