Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Mega-9 | 0.3%, 44% activation | Trichophyton rubrum | |
octyl beta-D-glucopyranoside | 0.3%, 42% activation | Trichophyton rubrum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amorolfine | 0.03 mM, 50% inhibition | Trichophyton rubrum | |
Mega-8 | 0.3%, 19% inhibition | Trichophyton rubrum | |
additional information | strong inhibition by allylamines | Trichophyton rubrum | |
SDZ 87-469 | 0.000020 mM, 50% inhibition | Trichophyton rubrum | |
terbinafine | 0.0000158 mM, 50% inhibition, non-competitive vs. squalene | Trichophyton rubrum | |
tolciclate | 0.000028 mM, 50% inhibition | Trichophyton rubrum | |
tolnaftate | 0.0000515 mM, 50% inhibition | Trichophyton rubrum | |
Triton X-100 | 0.3%, 71% inhibition | Trichophyton rubrum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0133 | - |
squalene | - |
Trichophyton rubrum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Trichophyton rubrum | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trichophyton rubrum | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000012 | - |
activity in microsomes | Trichophyton rubrum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
squalene + NAD(P)H + O2 | NADPH is slightly preferred | Trichophyton rubrum | (S)-squalene-2,3-epoxide + NADP+ + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | FAD stimulates activity but is not essential | Trichophyton rubrum |