Literature summary for 1.14.14.14 extracted from

Acar Cevik, U.; Kaya Cavusoglu, B.; Saglik, B.N.; Osmaniye, D.; Levent, S.; Ilgin, S.; Oezkay, Y.; Kaplancikli, Z.A.
Synthesis, docking studies and biological activity of new benzimidazole-triazolothiadiazine derivatives as aromatase inhibitor (2020), Molecules, 25, 1642 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-cyanophenyl)-7H-[1,2,4]triazole[3,4-b][1,3,4]thiadiazine	-	Homo sapiens
3-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-fluorophenyl)-7H-[1,2,4]triazole[3,4-b][1,3,4]thiadiazine	-	Homo sapiens
3-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-cyanophenyl)-7H-[1,2,4]triazole [3,4-b][1,3,4]thiadiazine	-	Homo sapiens
3-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-fluorophenyl)-7H-[1,2,4]triazole [3,4-b][1,3,4]thiadiazine	-	Homo sapiens
letrozole	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11511	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-
NIH-3T3 cell	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000024	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	letrozole
0.000032	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	3-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-cyanophenyl)-7H-[1,2,4]triazole[3,4-b][1,3,4]thiadiazine
0.00156	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	3-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-cyanophenyl)-7H-[1,2,4]triazole [3,4-b][1,3,4]thiadiazine
0.00172	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	3-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-fluorophenyl)-7H-[1,2,4]triazole[3,4-b][1,3,4]thiadiazine
0.00228	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	3-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenyl)-6-(4-fluorophenyl)-7H-[1,2,4]triazole [3,4-b][1,3,4]thiadiazine

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Release 2023.1 (January 2023)