Literature summary for 1.14.14.14 extracted from

Giampietro, L.; Gallorini, M.; Gambacorta, N.; Ammazzalorso, A.; De Filippis, B.; Della Valle, A.; Fantacuzzi, M.; Maccallini, C.; Mollica, A.; Cataldi, A.; Nicolotti, O.; Amoroso, R.
Synthesis, structure-activity relationships and molecular docking studies of phenyldiazenyl sulfonamides as aromatase inhibitors (2021), Eur. J. Med. Chem., 224, 113737 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(E)-2,4-dimethoxy-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide	not effective on HFF-1 cells	Homo sapiens
(E)-4-cyano-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide	not effective on HFF-1 cells	Homo sapiens
(E)-N-((1H-benzo[d]imidazole-2-yl)methyl)-2,4-dimethoxy-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide	treatment induces a dose-dependent increase of the percentage of cells found in the apoptotic stage, compound shows an anti-proliferative effect on MCF-7 cells, being blocked in the G1/S phase checkpoint. Compound is not effective on HFF-1 cells	Homo sapiens
resveratrol	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11511	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0016	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	(E)-2,4-dimethoxy-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide
0.0057	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	(E)-N-((1H-benzo[d]imidazole-2-yl)methyl)-2,4-dimethoxy-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide
0.0079	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	(E)-4-cyano-N-(4-(phenyldiazenyl)phenyl)benzenesulfonamide
0.08	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	resveratrol

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Release 2023.1 (January 2023)