Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7,8-Benzoflavone | competitive inhibitor, induces spectral changes in the aromatase cytochrome P450 | Homo sapiens | |
apigenin | - |
Homo sapiens | |
chrysin | competitive inhibitor, induces spectral changes in the aromatase cytochrome P450 | Homo sapiens | |
flavanone | - |
Homo sapiens | |
flavone | - |
Homo sapiens | |
additional information | not inhibitory: 5,6-benzoflavone | Homo sapiens | |
quercetin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | Homo sapiens | overall reaction | estrone + formate + 4 H2O + 3 oxidized flavoproteins | - |
? | |
testosterone + 3 O2 + 3 reduced flavoproteins | Homo sapiens | overall reaction | 17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ovary | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins | overall reaction | Homo sapiens | estrone + formate + 4 H2O + 3 oxidized flavoproteins | - |
? | |
testosterone + 3 O2 + 3 reduced flavoproteins | overall reaction | Homo sapiens | 17beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
cytochrome P450 | inhibitors 7,8-benzoflavone and chrysin induce spectral changes in the aromatase cytochrome P450 | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
substrate testosterone, pH 7.2, 37°C | Homo sapiens | 7,8-Benzoflavone | |
0.00007 | - |
substrate androst-4-ene-3,17-dione, pH 7.2, 37°C | Homo sapiens | 7,8-Benzoflavone | |
0.0004 | - |
substrate testosterone, pH 7.2, 37°C | Homo sapiens | chrysin | |
0.0005 | - |
substrate androst-4-ene-3,17-dione, pH 7.2, 37°C | Homo sapiens | chrysin | |
0.001 | - |
substrate testosterone, pH 7.2, 37°C | Homo sapiens | apigenin | |
0.0012 | - |
substrate androst-4-ene-3,17-dione, pH 7.2, 37°C | Homo sapiens | apigenin | |
0.005 | - |
substrate testosterone, pH 7.2, 37°C | Homo sapiens | flavone | |
0.005 | - |
substrate testosterone, pH 7.2, 37°C | Homo sapiens | flavanone | |
0.008 | - |
substrate androst-4-ene-3,17-dione, pH 7.2, 37°C | Homo sapiens | flavone | |
0.008 | - |
substrate androst-4-ene-3,17-dione, pH 7.2, 37°C | Homo sapiens | flavanone | |
0.01 | - |
substrate testosterone, pH 7.2, 37°C | Homo sapiens | quercetin | |
0.012 | - |
substrate androst-4-ene-3,17-dione, pH 7.2, 37°C | Homo sapiens | quercetin |