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Literature summary for 1.14.13.8 extracted from

  • Catucci, G.; Polignano, I.; Cusumano, D.; Medana, C.; Gilardi, G.; Sadeghi, S.J.
    Identification of human flavin-containing monooxygenase 3 substrates by a colorimetric screening assay (2017), Anal. Biochem., 522, 46-52 .
    View publication on PubMed
Search for more literature for 1.14.13.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Benzydamine i.e. 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine, 47% inhibition at 1 mM Homo sapiens
clomiphene i.e. 2-[4-[2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine, 60% inhibition at 0.05 mM Homo sapiens
selegiline i.e. (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine, 21% inhibition at 0.1 mM Homo sapiens
tamoxifen i.e. (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine, 55% inhibition at 1 mM Homo sapiens
tozasertib i.e. N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin2yl]sulfanylphenyl]cyclopropane carboxamide, 41% inhibition at 0.1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 tamoxifen pH and temperature not specified in the publication Homo sapiens
0.018
-
 clomiphene pH and temperature not specified in the publication Homo sapiens
0.023
-
 tozasertib pH and temperature not specified in the publication Homo sapiens
0.056
-
 Benzydamine pH and temperature not specified in the publication Homo sapiens
0.314
-
 selegiline pH and temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel affinity column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzydamine + NADPH + H+ + O2 i.e. 3-(1-benzyl-1H-indazol-3-yloxy)-N,N-dimethylpropan-1-amine Homo sapiens ?
-
 ?
clomiphene + NADPH + H+ + O2 i.e. 2-[4-[2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine Homo sapiens ?
-
 ?
methimazole + NADPH + H+ + O2
-
 Homo sapiens methimazole S-oxide + NADP+ + H2O
-
 ?
selegiline + NADPH + H+ + O2 i.e. (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine Homo sapiens ?
-
 ?
tamoxifen + NADPH + H+ + O2 i.e. (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine Homo sapiens ?
-
 ?
tozasertib + NADPH + H+ + O2 i.e. N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin2yl]sulfanylphenyl]cyclopropane carboxamide Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
flavin-containing monooxygenase 3
-
 Homo sapiens
FMO3
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0017
-
 clomiphene pH and temperature not specified in the publication Homo sapiens
0.023
-
 selegiline pH and temperature not specified in the publication Homo sapiens
0.15
-
 Benzydamine pH and temperature not specified in the publication Homo sapiens
0.155
-
 tozasertib pH and temperature not specified in the publication Homo sapiens
0.273
-
 tamoxifen pH and temperature not specified in the publication Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens