Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
13-deoxycarminomycin + NADPH + H+ + O2 | Streptomyces sp. | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | 13-dihydrocarminomycin + NADP+ + H2O | - |
? | |
13-deoxydaunorubicin + NADPH + H+ + O2 | Streptomyces sp. | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | 13-dihydrodaunorubicin + NADP+ + H2O | - |
? | |
13-dihydrocarminomycin + NADPH + H+ + O2 | Streptomyces sp. | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | carminomycin + NADP+ + H2O | - |
? | |
13-dihydrodaunorubicin + NADPH + H+ + O2 | Streptomyces sp. | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | daunorubicin + NADP+ + 2 H2O | - |
? | |
daunomycin + NADPH + H+ + O2 | Streptomyces sp. | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and 13-dihydrodaunorubicin and the hydroxylation at C-14 of daunorubicin | doxorubicin + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces sp. | Q59971 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
13-deoxycarminomycin + NADPH + H+ + O2 | - |
Streptomyces sp. | 13-dihydrocarminomycin + NADP+ + H2O | - |
? | |
13-deoxycarminomycin + NADPH + H+ + O2 | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | Streptomyces sp. | 13-dihydrocarminomycin + NADP+ + H2O | - |
? | |
13-deoxydaunorubicin + NADPH + H+ + O2 | - |
Streptomyces sp. | 13-dihydrodaunorubicin + NADP+ + H2O | i.e. daunorubicinol | ? | |
13-deoxydaunorubicin + NADPH + H+ + O2 | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | Streptomyces sp. | 13-dihydrodaunorubicin + NADP+ + H2O | - |
? | |
13-dihydrocarminomycin + NADPH + H+ + O2 | - |
Streptomyces sp. | carminomycin + NADP+ + H2O | - |
? | |
13-dihydrocarminomycin + NADPH + H+ + O2 | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | Streptomyces sp. | carminomycin + NADP+ + H2O | - |
? | |
13-dihydrodaunorubicin + NADPH + H+ + O2 | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and daunorubicinol and the hydroxylation at C-14 of daunorubicin | Streptomyces sp. | daunorubicin + NADP+ + 2 H2O | - |
? | |
13-dihydrodaunorubicin + NADPH + H+ + O2 | i.e. daunorubicinol | Streptomyces sp. | daunorubicin + NADP+ + 2 H2O | - |
? | |
daunomycin + NADPH + H+ + O2 | - |
Streptomyces sp. | doxorubicin + NADP+ + H2O | - |
? | |
daunomycin + NADPH + H+ + O2 | DoxA catalyzes three steps in the daunorubicin/doxorubicin biosynthesis pathway: hydroxylation at C13 of 13-deoxycarminomycin and 13-deoxydaunorubicin, oxidation at C-13 of 13-dihydrocarminomycin and 13-dihydrodaunorubicin and the hydroxylation at C-14 of daunorubicin | Streptomyces sp. | doxorubicin + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DoxA | - |
Streptomyces sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | reduced flavin adenine dinucleotide, reduced flavin mononucleotide, and NADH do not substitute for NADPH in these reactions | Streptomyces sp. |